Lrp12 MGI Mouse Gene Detail - MGI:2443132 - low density lipoprotein-related protein 12

Symbol

Lrp12
Name

low density lipoprotein-related protein 12
Synonyms

C820005L12Rik

Feature Type

protein coding gene
IDs

MGI:2443132
NCBI Gene: 239393
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr15:39733985-39807390 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 15.59 cM
Mapping Data

2 experiments

SNPs within 2kb

2279 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443132	protein coding gene	Chr15:39733985-39807417 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021818	protein coding gene	Chr15:38332282-38406977 (-)
A/J	MGP_AJ_G0021778	protein coding gene	Chr15:36828231-36907455 (-)
AKR/J	MGP_AKRJ_G0021759	protein coding gene	Chr15:37926373-38001122 (-)
BALB/cJ	MGP_BALBcJ_G0021785	protein coding gene	Chr15:36892291-36965522 (-)
C3H/HeJ	MGP_C3HHeJ_G0021559	protein coding gene	Chr15:37854181-37933609 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022224	protein coding gene	Chr15:39787909-39873714 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019761	protein coding gene	Chr15:34587021-34660402 (-)
CAST/EiJ	MGP_CASTEiJ_G0021076	protein coding gene	Chr15:38312089-38391381 (-)
CBA/J	MGP_CBAJ_G0021528	protein coding gene	Chr15:41213637-41287330 (-)
DBA/2J	MGP_DBA2J_G0021652	protein coding gene	Chr15:36678115-36754617 (-)
FVB/NJ	MGP_FVBNJ_G0021630	protein coding gene	Chr15:36057169-36131902 (-)
LP/J	MGP_LPJ_G0021722	protein coding gene	Chr15:38142798-38215963 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021654	protein coding gene	Chr15:44200619-44276306 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022247	protein coding gene	Chr15:38102129-38176365 (-)
PWK/PhJ	MGP_PWKPhJ_G0020821	protein coding gene	Chr15:36734067-36806653 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020658	protein coding gene	Chr15:37762391-37836247 (-)
WSB/EiJ	MGP_WSBEiJ_G0021131	protein coding gene	Chr15:38006942-38088875 (-)

Human Ortholog

LRP12, LDL receptor related protein 12

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LRP12, LDL receptor related protein 12
Synonyms

ALS28, MIG13A, ST7
Links

HGNC:31708

NCBI Gene ID: 29967

neXtProt AC: NX_Q9Y561

UniProt: Q9Y561
Chr Location

8q22.3; chr8:104489231-104589258 (-) GRCh38

MGI Vertebrate Homology

Lrp12 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LRP12
Gene Tree

Lrp12

Diseases

2 with human LRP12 associations

				Human Disease	Mouse Models
				amyotrophic lateral sclerosis type 28 IDs amyotrophic lateral sclerosis type 28 DOID:0081382 OMIM:620452
				oculopharyngodistal myopathy 1 IDs oculopharyngodistal myopathy 1 DOID:0081297 OMIM:164310

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

2
Endonuclease-mediated

2
Targeted

2
Genomic Mutations

2 involving Lrp12
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

9
GO References

5

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

840
Tissues

52
cDNA Data

33
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lrp12

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All Sequences

46
RefSeq

8
UniProt

2
CCDS

CCDS27446.1, CCDS84168.1

Ensembl

ENSMUSG00000022305 (Evidence)
NCBI Gene

239393

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022305	Ensembl Gene Model \| MGI Sequence Detail	73406	C57BL/6J	± kb
transcript	ENSMUST00000022916	Ensembl \| MGI Sequence Detail	4109	Not Applicable
polypeptide	ENSMUSP00000022916	Ensembl \| MGI Sequence Detail	858	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000009919 low-density lipoprotein receptor-related protein 12

(term hierarchy)
InterPro Domains

IPR000859 CUB domain

IPR036055 LDL receptor-like superfamily

IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site

IPR002172 Low-density lipoprotein (LDL) receptor class A repeat

IPR050685 Low-density lipoprotein receptor

IPR035914 Spermadhesin, CUB domain superfamily
GlyGen

Q8BUJ9 5 sites, 2 N-linked glycans (2 sites)

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All nucleic 33

cDNA 33

Microarray probesets 4

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MGI:2146083

Summaries

All 37

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 11
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:338432 Huang M, et al., LRP12 is an endogenous transmembrane inactivator of alpha4 integrins. Cell Rep. 2023 Jun 17;42(6):112667

TSS for Lrp12:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr134151	Chr15:39808047-39808062 (-)	-665 bp
Tssr134150	Chr15:39808003-39808022 (-)	-623 bp
Tssr134149	Chr15:39807920-39807940 (-)	-540 bp
Tssr134148	Chr15:39807867-39807887 (-)	-487 bp
Tssr134147	Chr15:39807359-39807425 (-)	-2 bp
Tssr134146	Chr15:39807316-39807327 (-)	68 bp
Tssr134145	Chr15:39807085-39807173 (-)	261 bp
Tssr134144	Chr15:39807025-39807036 (-)	359 bp
Tssr4585	Chr15:39774125-39774127 (-)	33,264 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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