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Ifi44 Gene Detail
Summary
  • Symbol
    Ifi44
  • Name
    interferon-induced protein 44
  • Synonyms
    A430056A10Rik, MTAP44, p44
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443016
    NCBI Gene: 99899
  • Alliance
    gene page
  • Transcription Start Sites
    41 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:151436559-151455580 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 76.91 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    679 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443016
 protein coding gene Chr3:151436559-151455597 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027983
 protein coding gene Chr3:155538776-155561087 (-)
A/J MGP_AJ_G0027942
 protein coding gene Chr3:149901349-149922809 (-)
AKR/J MGP_AKRJ_G0027908
 protein coding gene Chr3:153866762-153888026 (-)
BALB/cJ MGP_BALBcJ_G0027954
 protein coding gene Chr3:149741618-149769566 (-)
C3H/HeJ MGP_C3HHeJ_G0027684
 protein coding gene Chr3:154293429-154318342 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028397
 protein coding gene Chr3:160694446-160714640 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025735
 protein coding gene Chr3:144771634-144789754 (-)
CAST/EiJ MGP_CASTEiJ_G0027137
 protein coding gene Chr3:154363578-154384615 (-)
CBA/J MGP_CBAJ_G0027659
 protein coding gene Chr3:166422517-166443474 (-)
DBA/2J MGP_DBA2J_G0027799
 protein coding gene Chr3:149029743-149048768 (-)
FVB/NJ MGP_FVBNJ_G0027766
 protein coding gene Chr3:146417666-146436812 (-)
LP/J MGP_LPJ_G0027910
 protein coding gene Chr3:156913446-156932799 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027799
 protein coding gene Chr3:174985122-175004651 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028456
 protein coding gene Chr3:153568881-153587795 (-)
PWK/PhJ MGP_PWKPhJ_G0026860
 protein coding gene Chr3:148914059-148933662 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026688
 protein coding gene Chr3:151715457-151735485 (-)
WSB/EiJ MGP_WSBEiJ_G0027217
 protein coding gene Chr3:154554080-154572941 (-)



Homology
more
  • Human Ortholog
    IFI44, interferon induced protein 44
  • Vertebrate Orthologs
    18
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IFI44, interferon induced protein 44
  • Synonyms
    MTAP44, p44, TLDC5
  • Links
    NCBI Gene ID: 10561
    neXtProt AC: NX_Q8TCB0
    UniProt: Q8TCB0

  • Chr Location
    1p31.1; chr1:78649789-78664078 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased susceptibility to respiratory syncytial virus (RSV) infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    747
  • Tissues
    27
  • cDNA Data
    29
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 99899 NCBI Gene Model | MGI Sequence Detail 19022 C57BL/6J ±  kb
    transcript NM_133871 RefSeq | MGI Sequence Detail 2860 C57BL/6  
    polypeptide Q8BV66 UniProt | EBI | MGI Sequence Detail 422 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      cDNA 30

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2139980
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 6
      Gene Ontology 3
      Phenotypes 12
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:354587 Nedomova M, et al., DDI2 protease controls embryonic development and inflammation via TCF11/NRF1. iScience. 2024 Oct 18;27(10):110893
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory