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Ip6k3 Gene Detail
Summary
  • Symbol
    Ip6k3
  • Name
    inositol hexaphosphate kinase 3
  • Synonyms
    D830007E07Rik, Ihpk3
  • Feature Type
    protein coding gene
  • IDs
    MGI:3045325
    NCBI Gene: 271424
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:27362945-27386738 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 17, 13.77 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    845 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3045325
protein coding gene Chr17:27362939-27386769 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023418
protein coding gene Chr17:26394364-26419659 (-)
A/J MGP_AJ_G0023375
protein coding gene Chr17:25588440-25611880 (-)
AKR/J MGP_AKRJ_G0023341
protein coding gene Chr17:25728218-25752045 (-)
BALB/cJ MGP_BALBcJ_G0023380
protein coding gene Chr17:25831457-25855037 (-)
C3H/HeJ MGP_C3HHeJ_G0023141
protein coding gene Chr17:26102556-26128060 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023823
protein coding gene Chr17:27513262-27526182 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021297
protein coding gene Chr17:22992786-23006125 (-)
CAST/EiJ MGP_CASTEiJ_G0022642
protein coding gene Chr17:26032332-26061276 (-)
CBA/J MGP_CBAJ_G0023115
protein coding gene Chr17:28467236-28494521 (-)
DBA/2J MGP_DBA2J_G0023247
protein coding gene Chr17:25150577-25173900 (-)
FVB/NJ MGP_FVBNJ_G0023216
protein coding gene Chr17:24929034-24953540 (-)
LP/J MGP_LPJ_G0023324
protein coding gene Chr17:26642672-26666171 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023234
protein coding gene Chr17:27980539-28004050 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023864
protein coding gene Chr17:26102767-26127059 (-)
PWK/PhJ MGP_PWKPhJ_G0022392
protein coding gene Chr17:23944690-23968825 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022210
protein coding gene Chr17:24147621-24182924 (-)
WSB/EiJ MGP_WSBEiJ_G0022705
protein coding gene Chr17:26129273-26153641 (-)



Homology
more
  • Human Ortholog
    IP6K3, inositol hexakisphosphate kinase 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IP6K3, inositol hexakisphosphate kinase 3
  • Synonyms
    IHPK3, INSP6K3
  • Links
    NCBI Gene ID: 117283
    neXtProt AC: NX_Q96PC2
    UniProt: Q96PC2

  • Chr Location
    6p21.31; chr6:33721662-33762145 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit altered cerebellar Purkinje cell morphology, reduced synapse number, and defects in motor learning and coordination.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 271424 NCBI Gene Model | MGI Sequence Detail 23794 C57BL/6J ±  kb
    transcript NM_173027 RefSeq | MGI Sequence Detail 2305 C57BL/6  
    polypeptide Q8BWD2 UniProt | EBI | MGI Sequence Detail 396 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 1
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 2
      Gene Ontology 10
      Phenotypes 9
    • Earliest
      J:114043 Saiardi A, et al., Identification and characterization of a novel inositol hexakisphosphate kinase. J Biol Chem. 2001 Oct 19;276(42):39179-85
    • Latest
      J:327597 Li H, et al., Inositol hexakisphosphate kinases differentially regulate trafficking of vesicular glutamate transporters 1 and 2. Front Cell Neurosci. 2022;16:926794

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    11/19/2024
    MGI 6.24
    The Jackson Laboratory