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Acot4 Gene Detail
Summary
  • Symbol
    Acot4
  • Name
    acyl-CoA thioesterase 4
  • Synonyms
    B430212I04Rik, Pte2b, PTE-Ib
  • Feature Type
    protein coding gene
  • IDs
    MGI:2159621
    NCBI Gene: 171282
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr12:84084028-84091497 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 39.01 cM, cytoband D3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    253 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2159621
 protein coding gene Chr12:84084028-84095375 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019924
 protein coding gene Chr12:84717957-84725007 (+)
A/J MGP_AJ_G0019881
 protein coding gene Chr12:81503855-81510197 (+)
AKR/J MGP_AKRJ_G0019857
 protein coding gene Chr12:83712407-83718751 (+)
BALB/cJ MGP_BALBcJ_G0019861
 protein coding gene Chr12:81841322-81847670 (+)
C3H/HeJ MGP_C3HHeJ_G0019667
 protein coding gene Chr12:84182974-84190231 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020312
 protein coding gene Chr12:87145143-87153098 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017928
 protein coding gene Chr12:78370469-78431106 (+)
CAST/EiJ MGP_CASTEiJ_G0019216
 protein coding gene Chr12:79119128-79125310 (+)
CBA/J MGP_CBAJ_G0019638
 protein coding gene Chr12:90488109-90494489 (+)
DBA/2J MGP_DBA2J_G0019753
 protein coding gene Chr12:81043428-81049646 (+)
FVB/NJ MGP_FVBNJ_G0019739
 protein coding gene Chr12:79996388-80002755 (+)
LP/J MGP_LPJ_G0019825
 protein coding gene Chr12:84590452-84599316 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019778
 protein coding gene Chr12:93449979-93457502 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020346
 protein coding gene Chr12:83318896-83325239 (+)
PWK/PhJ MGP_PWKPhJ_G0018980
 protein coding gene Chr12:75531147-75537463 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018775
 protein coding gene Chr12:77793705-77801763 (+)
WSB/EiJ MGP_WSBEiJ_G0019268
 protein coding gene Chr12:83983054-83989401 (+)



Homology
more
  • Human Ortholog
    ACOT4, acyl-CoA thioesterase 4
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACOT4, acyl-CoA thioesterase 4
  • Synonyms
    PTE1B, PTE2B, PTE-Ib
  • Links
    NCBI Gene ID: 122970
    neXtProt AC: NX_Q8N9L9
    UniProt: Q8N9L9

  • Chr Location
    14q24.3; chr14:73591873-73595766 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Acot4
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    22 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    829
  • Tissues
    100
  • cDNA Data
    7
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 171282 NCBI Gene Model | MGI Sequence Detail 7470 C57BL/6J ±  kb
transcript NM_134247 RefSeq | MGI Sequence Detail 2325 C57BL/6  
polypeptide Q8BWN8 UniProt | EBI | MGI Sequence Detail 421 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000003637 peroxisomal succinyl-coenzyme A thioesterase
    (term hierarchy)
  • EC
    3.1.2.3
  • InterPro Domains
    IPR016662 Acyl-CoA thioesterase, long chain
    IPR042490 Acyl-CoA thioester hydrolase/BAAT, N-terminal
    IPR006862 Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase
    IPR029058 Alpha/Beta hydrolase fold
    IPR014940 BAAT/Acyl-CoA thioester hydrolase C-terminal
  • GlyGen
    Q8BWN8 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 7
    cDNA 7

    Microarray probesets 3
Other
Accession IDs
less
MGI:2444321
References
more
  • Summaries
    All 39
    Developmental Gene Expression 4
    Gene Ontology 9
    Phenotypes 10
  • Earliest
    J:59046 Hunt MC, et al., Peroxisome proliferator-induced long chain acyl-CoA thioesterases comprise a highly conserved novel multi-gene family involved in lipid metabolism. J Biol Chem. 1999 Nov 26;274(48):34317-26
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory