Cip2a MGI Mouse Gene Detail - MGI:2146335 - cell proliferation regulating inhibitor of protein phosphatase 2A

Symbol

Cip2a
Name

cell proliferation regulating inhibitor of protein phosphatase 2A
Synonyms

C330027C09Rik, Cip2a

Feature Type

protein coding gene
IDs

MGI:2146335
NCBI Gene: 224171
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr16:48814548-48840072 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 30.75 cM
Mapping Data

2 experiments

SNPs within 2kb

673 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2146335	protein coding gene	Chr16:48814524-48840079 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022871	protein coding gene	Chr16:47874760-47900279 (+)
A/J	MGP_AJ_G0022837	protein coding gene	Chr16:45768488-45793926 (+)
AKR/J	MGP_AKRJ_G0022809	protein coding gene	Chr16:47291163-47316689 (+)
BALB/cJ	MGP_BALBcJ_G0022838	protein coding gene	Chr16:45810834-45836421 (+)
C3H/HeJ	MGP_C3HHeJ_G0022601	protein coding gene	Chr16:47365620-47391109 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023285	protein coding gene	Chr16:49087813-49113328 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020798	protein coding gene	Chr16:45874809-45900416 (+)
CAST/EiJ	MGP_CASTEiJ_G0022127	protein coding gene	Chr16:47656283-47685980 (+)
CBA/J	MGP_CBAJ_G0022574	protein coding gene	Chr16:50989087-51014556 (+)
DBA/2J	MGP_DBA2J_G0022705	protein coding gene	Chr16:45494952-45523536 (+)
FVB/NJ	MGP_FVBNJ_G0022681	protein coding gene	Chr16:45377281-45402776 (+)
LP/J	MGP_LPJ_G0022773	protein coding gene	Chr16:47629964-47659689 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022699	protein coding gene	Chr16:50737792-50776935 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023300	protein coding gene	Chr16:47305295-47331580 (+)
PWK/PhJ	MGP_PWKPhJ_G0021867	protein coding gene	Chr16:45830564-45856380 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021697	protein coding gene	Chr16:47157341-47184524 (+)
WSB/EiJ	MGP_WSBEiJ_G0022172	protein coding gene	Chr16:47349037-47374553 (+)

Human Ortholog

CIP2A, cellular inhibitor of PP2A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CIP2A, cellular inhibitor of PP2A
Synonyms

KIAA1524, NOCIVA, p90
Links

HGNC:29302

NCBI Gene ID: 57650

neXtProt AC: NX_Q8TCG1

UniProt: Q8TCG1
Chr Location

3q13.13; chr3:108549864-108589644 (-) GRCh38

MGI Vertebrate Homology

Cip2a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CIP2A
Gene Tree

Cip2a

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
2 images
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

2
Gene trapped

8
Transgenic

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

44 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a hypomorphic allele display oligozoospermia, small epididymis and impaired spermatogonial progenitor cell maintenance.

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All GO Annotations

19
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

723
Tissues

10
cDNA Data

11
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cip2a

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All Sequences

53
RefSeq

6
UniProt

2
CCDS

CCDS49867.1

Ensembl

ENSMUSG00000033031 (Evidence)
NCBI Gene

224171

			Length	Strain/Species	Flank
genomic	ENSMUSG00000033031	Ensembl Gene Model \| MGI Sequence Detail	25525	C57BL/6J	± kb
transcript	ENSMUST00000048374	Ensembl \| MGI Sequence Detail	3974	Not Applicable
polypeptide	ENSMUSP00000044714	Ensembl \| MGI Sequence Detail	907	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000045178 protein CIP2A

(term hierarchy)
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR048701 CIP2A, N-terminal

IPR042510 Protein CIP2A

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All nucleic 11

cDNA 11

Microarray probesets 5

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MGI:2146550, MGI:6154701

Summaries

All 35

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 8
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:311352 Zhou Y, et al., Polyphyllin I attenuates cognitive impairments and reduces AD-like pathology through CIP2A-PP2A signaling pathway in 3XTg-AD mice. FASEB J. 2020 Dec;34(12):16414-16431

TSS for Cip2a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr138707	Chr16:48814560-48814602 (+)	33 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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