Gk5 MGI Mouse Gene Detail - MGI:2443336

Symbol

Gk5
Name

glycerol kinase 5
Synonyms

C330018K18Rik, G630067D24Rik

Feature Type

protein coding gene
IDs

MGI:2443336
NCBI Gene: 235533
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr9:96001415-96066661 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 50.31 cM
Mapping Data

2 experiments

SNPs within 2kb

1973 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443336	protein coding gene	Chr9:96001379-96066680 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035141	protein coding gene	Chr9:97281713-97357477 (+)
A/J	MGP_AJ_G0035122	protein coding gene	Chr9:93895266-93964861 (+)
AKR/J	MGP_AKRJ_G0035054	protein coding gene	Chr9:96177917-96247232 (+)
BALB/cJ	MGP_BALBcJ_G0035115	protein coding gene	Chr9:93583757-93653952 (+)
C3H/HeJ	MGP_C3HHeJ_G0034825	protein coding gene	Chr9:96598825-96670318 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035635	protein coding gene	Chr9:100065914-100152149 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032536	protein coding gene	Chr9:91722457-91739036 (+)
CAST/EiJ	MGP_CASTEiJ_G0034137	protein coding gene	Chr9:96345162-96418336 (+)
CBA/J	MGP_CBAJ_G0034793	protein coding gene	Chr9:103544561-103624708 (+)
DBA/2J	MGP_DBA2J_G0034955	protein coding gene	Chr9:93422968-93489496 (+)
FVB/NJ	MGP_FVBNJ_G0034903	protein coding gene	Chr9:92271962-92338907 (+)
LP/J	MGP_LPJ_G0035034	protein coding gene	Chr9:97556921-97630511 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034942	protein coding gene	Chr9:105543422-105614238 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035657	protein coding gene	Chr9:96406977-96475767 (+)
PWK/PhJ	MGP_PWKPhJ_G0033844	protein coding gene	Chr9:93580171-93648812 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033679	protein coding gene	Chr9:96421691-96529138 (+)
WSB/EiJ	MGP_WSBEiJ_G0034257	protein coding gene	Chr9:96277195-96347423 (+)

Human Ortholog

GK5, glycerol kinase 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GK5, glycerol kinase 5
Links

HGNC:28635

NCBI Gene ID: 256356

neXtProt AC: NX_Q6ZS86

UniProt: Q6ZS86
Chr Location

3q23; chr3:142157527-142225592 (-) GRCh38

MGI Vertebrate Homology

Gk5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GK5
Protein SuperFamily

GlpK
Gene Tree

Gk5

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Phenotype Summary

21 phenotypes from 6 alleles in 6 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Chemically induced (ENU)

5
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

11
Targeted

2
Genomic Mutations

1 involving Gk5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

44 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for ENU-induced alleles exhibit skin phenotype and alopecia.

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All GO Annotations

10
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

721
Tissues

2
cDNA Data

37
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gk5

ZFIN gk5

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All Sequences

60
RefSeq

13
UniProt

2
CCDS

CCDS52891.1, CCDS90642.1

Ensembl

ENSMUSG00000041440 (Evidence)
NCBI Gene

235533

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041440	Ensembl Gene Model \| MGI Sequence Detail	65247	C57BL/6J	± kb
transcript	ENSMUST00000085217	Ensembl \| MGI Sequence Detail	2815	Not Applicable
polypeptide	ENSMUSP00000082313	Ensembl \| MGI Sequence Detail	534	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000029111 putative glycerol kinase 5

(term hierarchy)
EC

2.7.1.30
InterPro Domains

IPR043129 ATPase, nucleotide binding domain

IPR000577 Carbohydrate kinase, FGGY

IPR018483 Carbohydrate kinase, FGGY, conserved site

IPR018485 Carbohydrate kinase FGGY, C-terminal

IPR018484 Carbohydrate kinase FGGY, N-terminal

IPR037444 Putative glycerol kinase 5, FGGY

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All nucleic 37

cDNA 37

Microarray probesets 3

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MGI:2444291, MGI:3034778

Summaries

All 34

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 12
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:243852 Zhang D, et al., Skin-specific regulation of SREBP processing and lipid biosynthesis by glycerol kinase 5. Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):E5197-E5206

TSS for Gk5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr86586	Chr9:96001475-96001490 (+)	68 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24