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Mdfic Gene Detail
Summary
  • Symbol
    Mdfic
  • Name
    MyoD family inhibitor domain containing
  • Synonyms
    clone 1.5, Kdt1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104611
    NCBI Gene: 16543
  • Alliance
    gene page
  • Transcription Start Sites
    25 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:15720660-15802168 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 6.85 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2550 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104611
 protein coding gene Chr6:15720660-15802168 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030465
 protein coding gene Chr6:12888181-12971505 (+)
A/J MGP_AJ_G0030438
 protein coding gene Chr6:12365666-12447600 (+)
AKR/J MGP_AKRJ_G0030365
 protein coding gene Chr6:12824154-12907144 (+)
BALB/cJ MGP_BALBcJ_G0030447
 protein coding gene Chr6:12431450-12512820 (+)
C3H/HeJ MGP_C3HHeJ_G0030161
 protein coding gene Chr6:12701007-12787223 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030902
 protein coding gene Chr6:13326042-13409688 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028113
 protein coding gene Chr6:11414490-11496595 (+)
CAST/EiJ MGP_CASTEiJ_G0029563
 protein coding gene Chr6:12556285-12642773 (+)
CBA/J MGP_CBAJ_G0030139
 protein coding gene Chr6:13713107-13800280 (+)
DBA/2J MGP_DBA2J_G0030283
 protein coding gene Chr6:12297217-12379102 (+)
FVB/NJ MGP_FVBNJ_G0030237
 protein coding gene Chr6:12161627-12242872 (+)
LP/J MGP_LPJ_G0030370
 protein coding gene Chr6:12958519-13043993 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030273
 protein coding gene Chr6:14746481-14831710 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030932
 protein coding gene Chr6:12685625-12769172 (+)
PWK/PhJ MGP_PWKPhJ_G0029277
 protein coding gene Chr6:11952228-12035499 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029113
 protein coding gene Chr6:12526936-12606535 (+)
WSB/EiJ MGP_WSBEiJ_G0029639
 protein coding gene Chr6:12629082-12715482 (+)



Homology
more
  • Human Ortholog
    MDFIC, MyoD family inhibitor domain containing
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MDFIC, MyoD family inhibitor domain containing
  • Synonyms
    HIC, LMPHM12, MDFIC1
  • Links
    NCBI Gene ID: 29969
    neXtProt AC: NX_Q9P1T7
    UniProt: Q9P1T7

  • Chr Location
    7q31.1-q31.2; chr7:114922094-115019917 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Mdfic mouse models; 1 with human MDFIC associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    745
  • Tissues
    4
  • cDNA Data
    14
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16543 NCBI Gene Model | MGI Sequence Detail 81509 C57BL/6J ±  kb
    transcript NM_175088 RefSeq | MGI Sequence Detail 3435 C57BL/6  
    polypeptide Q8BX65 UniProt | EBI | MGI Sequence Detail 247 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000010260 MyoD family inhibitor domain-containing protein
      (term hierarchy)
    • PDB
      8IMZ
    • InterPro Domains
      IPR026134 MyoD family inhibitor/MyoD family inhibitor domain-containing protein
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 15
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-26048
    References
    more
    • Summaries
      All 30
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 7
      Phenotypes 4
    • Earliest
      J:26723 Thompson HA, et al., Tissue-specific expression of novel messenger ribonucleic acids cloned from a renin-expressing kidney tumor cell line (As4.1). Endocrinology. 1995 Jul;136(7):3037-45
    • Latest
      J:326462 Byrne AB, et al., Pathogenic variants in MDFIC cause recessive central conducting lymphatic anomaly with lymphedema. Sci Transl Med. 2022 Mar 2;14(634):eabm4869
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory