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Peli3 Gene Detail
Summary
  • Symbol
    Peli3
  • Name
    pellino 3
  • Synonyms
    6030441F14Rik, MGC:30417
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924963
    NCBI Gene: 240518
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:4979745-4993155 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 4.17 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    370 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924963
 protein coding gene Chr19:4979745-4993155 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024682
 protein coding gene Chr19:1843240-1858183 (-)
A/J MGP_AJ_G0024648
 protein coding gene Chr19:1749368-1761515 (-)
AKR/J MGP_AKRJ_G0024621
 protein coding gene Chr19:1795664-1807687 (-)
BALB/cJ MGP_BALBcJ_G0024648
 protein coding gene Chr19:1742978-1755184 (-)
C3H/HeJ MGP_C3HHeJ_G0024416
 protein coding gene Chr19:1798189-1810183 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025095
 protein coding gene Chr19:1899518-1913633 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022525
 protein coding gene Chr19:1683803-1697172 (-)
CAST/EiJ MGP_CASTEiJ_G0023888
 protein coding gene Chr19:1828315-1840575 (-)
CBA/J MGP_CBAJ_G0024387
 protein coding gene Chr19:1975054-1992354 (-)
DBA/2J MGP_DBA2J_G0024515
 protein coding gene Chr19:1716163-1743796 (-)
FVB/NJ MGP_FVBNJ_G0024482
 protein coding gene Chr19:1738747-1751524 (-)
LP/J MGP_LPJ_G0024601
 protein coding gene Chr19:1845277-1859424 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024512
 protein coding gene Chr19:1869171-1884393 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025143
 protein coding gene Chr19:1793971-1805961 (-)
PWK/PhJ MGP_PWKPhJ_G0023634
 protein coding gene Chr19:1767994-1780740 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023439
 protein coding gene Chr19:1780702-1793053 (-)
WSB/EiJ MGP_WSBEiJ_G0023950
 protein coding gene Chr19:1798228-1822312 (-)



Homology
more
  • Human Ortholog
    PELI3, pellino E3 ubiquitin protein ligase family member 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PELI3, pellino E3 ubiquitin protein ligase family member 3
  • Links
    NCBI Gene ID: 246330
    neXtProt AC: NX_Q8N2H9
    UniProt: Q8N2H9

  • Chr Location
    11q13.2; chr11:66466327-66477337 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display decreased susceptibility to viral infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    730
  • Tissues
    11
  • cDNA Data
    26
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 240518 NCBI Gene Model | MGI Sequence Detail 13411 C57BL/6J ±  kb
    transcript NM_001347422 RefSeq | MGI Sequence Detail 3975 C57BL/6  
    polypeptide Q8BXR6 UniProt | EBI | MGI Sequence Detail 445 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 26

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:2679258
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 14
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory