Nuak2 MGI Mouse Gene Detail - MGI:1921387 - NUAK family, SNF1-like kinase, 2

Symbol

Nuak2
Name

NUAK family, SNF1-like kinase, 2
Synonyms

1200013B22Rik, mKIAA0537, Snark

Feature Type

protein coding gene
IDs

MGI:1921387
NCBI Gene: 74137
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr1:132243864-132261226 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 57.24 cM, cytoband E4
Mapping Data

2 experiments

SNPs within 2kb

464 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921387	protein coding gene	Chr1:132243827-132261233 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016470	protein coding gene	Chr1:135791562-135810015 (+)
A/J	MGP_AJ_G0016453	protein coding gene	Chr1:130758823-130776721 (+)
AKR/J	MGP_AKRJ_G0016418	protein coding gene	Chr1:134607858-134624947 (+)
BALB/cJ	MGP_BALBcJ_G0016413	protein coding gene	Chr1:131092587-131110001 (+)
C3H/HeJ	MGP_C3HHeJ_G0016239	protein coding gene	Chr1:134754802-134773469 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016874	protein coding gene	Chr1:140834186-140852923 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014585	protein coding gene	Chr1:123903626-123920755 (+)
CAST/EiJ	MGP_CASTEiJ_G0015819	protein coding gene	Chr1:133749340-133769609 (+)
CBA/J	MGP_CBAJ_G0016211	protein coding gene	Chr1:145640671-145657804 (+)
DBA/2J	MGP_DBA2J_G0016318	protein coding gene	Chr1:129724685-129742013 (+)
FVB/NJ	MGP_FVBNJ_G0016317	protein coding gene	Chr1:128354458-128371561 (+)
LP/J	MGP_LPJ_G0016389	protein coding gene	Chr1:137100701-137119633 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016342	protein coding gene	Chr1:151441125-151458272 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016910	protein coding gene	Chr1:134360489-134377578 (+)
PWK/PhJ	MGP_PWKPhJ_G0015605	protein coding gene	Chr1:128714105-128731762 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015392	protein coding gene	Chr1:133321599-133340859 (+)
WSB/EiJ	MGP_WSBEiJ_G0015881	protein coding gene	Chr1:134358336-134376579 (+)

Human Ortholog

NUAK2, NUAK family kinase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NUAK2, NUAK family kinase 2
Synonyms

ANPH2, SNARK
Links

HGNC:29558

NCBI Gene ID: 81788

neXtProt AC: NX_Q9H093

UniProt: Q9H093
Chr Location

1q32.1; chr1:205302063-205321745 (-) GRCh38

MGI Vertebrate Homology

Nuak2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NUAK2
Gene Tree

Nuak2

Diseases

1 with human NUAK2 associations

				Human Disease	Mouse Models
				anencephaly IDs anencephaly DOID:0060668 ICD10CM:Q00.0 MESH:D000757 OMIM:206500 ORDO:1048

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
10 phenotypes from multigenic genotypes
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

2
Gene trapped

2
Radiation induced

1
Targeted

6
Genomic Mutations

3 involving Nuak2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Most homozygous null mice are exencephalic and die at E16.5 while survivors show a higher number of azoxymethane (AOM)-induced aberrant crypt foci (ACF) in colon. Heterozygotes show increased susceptibility to AOM-induced ACF formation and colon tumors, mature-onset obesity and metabolic disorders.

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All GO Annotations

47
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

22
cDNA Data

50
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nuak2

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All Sequences

44
RefSeq

10
UniProt

1
CCDS

CCDS15283.1, CCDS56642.1

Ensembl

ENSMUSG00000009772 (Evidence)
NCBI Gene

74137

			Length	Strain/Species	Flank
genomic	ENSMUSG00000009772	Ensembl Gene Model \| MGI Sequence Detail	17363	C57BL/6J	± kb
transcript	ENSMUST00000072177	Ensembl \| MGI Sequence Detail	2936	Not Applicable
polypeptide	ENSMUSP00000072039	Ensembl \| MGI Sequence Detail	639	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000011474 NUAK family SNF1-like kinase 2

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 51

cDNA 50

Primer pair 1

Microarray probesets 2

Summaries

All 51

Developmental Gene Expression 6

Gene Ontology 8

Phenotypes 15
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:317099 Queiroz AL, et al., The MicroRNA miR-696 is regulated by SNARK and reduces mitochondrial activity in mouse skeletal muscle through Pgc1alpha inhibition. Mol Metab. 2021 Mar 31;51:101226

TSS for Nuak2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8734	Chr1:132243824-132243831 (+)	-36 bp
Tssr8735	Chr1:132243850-132243882 (+)	2 bp
Tssr8736	Chr1:132243938-132243949 (+)	80 bp
Tssr8737	Chr1:132257701-132257724 (+)	13,849 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24