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Nhlrc2 Gene Detail
Summary
  • Symbol
    Nhlrc2
  • Name
    NHL repeat containing 2
  • Synonyms
    1200003G01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914116
    NCBI Gene: 66866
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:56536693-56591935 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 51.89 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1447 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914116
 protein coding gene Chr19:56536682-56591935 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025266
 protein coding gene Chr19:56908200-56961670 (+)
A/J MGP_AJ_G0025242
 protein coding gene Chr19:54090474-54141492 (+)
AKR/J MGP_AKRJ_G0025211
 protein coding gene Chr19:55801449-55853777 (+)
BALB/cJ MGP_BALBcJ_G0025237
 protein coding gene Chr19:54173779-54223894 (+)
C3H/HeJ MGP_C3HHeJ_G0024997
 protein coding gene Chr19:56039584-56092383 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025680
 protein coding gene Chr19:58277736-58331138 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023092
 protein coding gene Chr19:53020596-53069802 (+)
CAST/EiJ MGP_CASTEiJ_G0024462
 protein coding gene Chr19:56062946-56130930 (+)
CBA/J MGP_CBAJ_G0024977
 protein coding gene Chr19:61167741-61222858 (+)
DBA/2J MGP_DBA2J_G0025109
 protein coding gene Chr19:53882683-53933226 (+)
FVB/NJ MGP_FVBNJ_G0025070
 protein coding gene Chr19:53583746-53635825 (+)
LP/J MGP_LPJ_G0025195
 protein coding gene Chr19:56766156-56817590 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025103
 protein coding gene Chr19:60451201-60503780 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025738
 protein coding gene Chr19:56003457-56057527 (+)
PWK/PhJ MGP_PWKPhJ_G0024210
 protein coding gene Chr19:53840796-53891207 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024013
 protein coding gene Chr19:54687906-54752983 (+)
WSB/EiJ MGP_WSBEiJ_G0024532
 protein coding gene Chr19:56148390-56201509 (+)



Homology
more
  • Human Ortholog
    NHLRC2, NHL repeat containing 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NHLRC2, NHL repeat containing 2
  • Synonyms
    FINCA
  • Links
    NCBI Gene ID: 374354
    neXtProt AC: NX_Q8NBF2
    UniProt: Q8NBF2

  • Chr Location
    10q25.3; chr10:113854661-113917194 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal trophoblast layer formation and complete embryonic lethality during organogenesis with a failure to gastrulate. Mice compound heterozygous for a KO allele and a human disease-associated point mutation show no phenotype but show a possible effect on RNA homeostasis in neurons.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    2
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    814
  • Tissues
    51
  • cDNA Data
    9
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025078 Ensembl Gene Model | MGI Sequence Detail 55243 C57BL/6J ±  kb
    transcript ENSMUST00000071423 Ensembl | MGI Sequence Detail 8591 Not Applicable  
    polypeptide ENSMUSP00000071370 Ensembl | MGI Sequence Detail 725 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2147596, MGI:2147664, MGI:2147734
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 3
      Gene Ontology 2
      Phenotypes 15
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory