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Wwp1 Gene Detail
Summary
  • Symbol
    Wwp1
  • Name
    WW domain containing E3 ubiquitin protein ligase 1
  • Synonyms
    8030445B08Rik, AIP5, SDRP1, Tiul1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861728
    NCBI Gene: 107568
  • Alliance
    gene page
  • Transcription Start Sites
    27 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:19608303-19708993 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 7.56 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2824 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1861728
 protein coding gene Chr4:19608296-19709004 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028083
 protein coding gene Chr4:16641619-16736244 (-)
A/J MGP_AJ_G0028041
 protein coding gene Chr4:16169927-16263805 (-)
AKR/J MGP_AKRJ_G0028006
 protein coding gene Chr4:16522155-16621923 (-)
BALB/cJ MGP_BALBcJ_G0028052
 protein coding gene Chr4:16142430-16239468 (-)
C3H/HeJ MGP_C3HHeJ_G0027782
 protein coding gene Chr4:16628215-16725733 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028495
 protein coding gene Chr4:17298768-17399981 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025837
 protein coding gene Chr4:14964471-15057989 (-)
CAST/EiJ MGP_CASTEiJ_G0027237
 protein coding gene Chr4:16442024-16540680 (-)
CBA/J MGP_CBAJ_G0027755
 protein coding gene Chr4:17799028-17903064 (-)
DBA/2J MGP_DBA2J_G0027898
 protein coding gene Chr4:15979273-16076732 (-)
FVB/NJ MGP_FVBNJ_G0027864
 protein coding gene Chr4:15703160-15803011 (-)
LP/J MGP_LPJ_G0028007
 protein coding gene Chr4:16669834-16772213 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027897
 protein coding gene Chr4:18842762-18951043 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028554
 protein coding gene Chr4:16415065-16514310 (-)
PWK/PhJ MGP_PWKPhJ_G0026957
 protein coding gene Chr4:15877252-15972136 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026786
 protein coding gene Chr4:16288060-16384014 (-)
WSB/EiJ MGP_WSBEiJ_G0027314
 protein coding gene Chr4:16472089-16568851 (-)



Homology
more
  • Human Ortholog
    WWP1, WW domain containing E3 ubiquitin protein ligase 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WWP1, WW domain containing E3 ubiquitin protein ligase 1
  • Synonyms
    AIP5, hSDRP1, Tiul1
  • Links
    NCBI Gene ID: 11059
    neXtProt AC: NX_Q9H0M0
    UniProt: Q9H0M0

  • Chr Location
    8q21.3; chr8:86342547-86478420 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased osteoblast differentiation of bone marrow-derived stromal cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    3
  • cDNA Data
    28
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041058 Ensembl Gene Model | MGI Sequence Detail 100691 C57BL/6J ±  kb
    transcript ENSMUST00000108246 Ensembl | MGI Sequence Detail 6440 Not Applicable  
    polypeptide ENSMUSP00000103881 Ensembl | MGI Sequence Detail 918 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      Genomic 1
      cDNA 28
      Primer pair 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:2444949
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 19
    • Earliest
      J:63602 Huang K, et al., A HECT domain ubiquitin ligase closely related to the mammalian protein WWP1 is essential for Caenorhabditis elegans embryogenesis. Gene. 2000 Jul 11;252(1-2):137-45
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory