Dzank1 MGI Mouse Gene Detail - MGI:2139080 - double zinc ribbon and ankyrin repeat domains 1

Symbol

Dzank1
Name

double zinc ribbon and ankyrin repeat domains 1
Synonyms

2810039F03Rik, 6330439K17Rik, Ankrd64

Feature Type

protein coding gene
IDs

MGI:2139080
NCBI Gene: 241688
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr2:144312477-144369334 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 71.02 cM
Mapping Data

2 experiments

SNPs within 2kb

1859 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2139080	protein coding gene	Chr2:144312475-144369427 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026586	protein coding gene	Chr2:148573973-148633578 (-)
A/J	MGP_AJ_G0026550	protein coding gene	Chr2:142557385-142614987 (-)
AKR/J	MGP_AKRJ_G0026524	protein coding gene	Chr2:146649000-146707228 (-)
BALB/cJ	MGP_BALBcJ_G0026562	protein coding gene	Chr2:142993692-143051677 (-)
C3H/HeJ	MGP_C3HHeJ_G0026305	protein coding gene	Chr2:147193021-147251293 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027007	protein coding gene	Chr2:153019692-153081438 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024384	protein coding gene	Chr2:136730527-136788365 (-)
CAST/EiJ	MGP_CASTEiJ_G0025766	protein coding gene	Chr2:147526849-147586716 (-)
CBA/J	MGP_CBAJ_G0026285	protein coding gene	Chr2:158604974-158670103 (-)
DBA/2J	MGP_DBA2J_G0026419	protein coding gene	Chr2:141837370-141895181 (-)
FVB/NJ	MGP_FVBNJ_G0026383	protein coding gene	Chr2:140419408-140475398 (-)
LP/J	MGP_LPJ_G0026523	protein coding gene	Chr2:148723478-148780510 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026403	protein coding gene	Chr2:162794582-162858343 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027062	protein coding gene	Chr2:146640451-146698938 (-)
PWK/PhJ	MGP_PWKPhJ_G0025502	protein coding gene	Chr2:141495105-141557823 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025303	protein coding gene	Chr2:145685902-145746875 (-)
WSB/EiJ	MGP_WSBEiJ_G0025839	protein coding gene	Chr2:147652360-147711867 (-)

Human Ortholog

DZANK1, double zinc ribbon and ankyrin repeat domains 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DZANK1, double zinc ribbon and ankyrin repeat domains 1
Synonyms

ANKRD64, C20orf12, C20orf84
Links

HGNC:15858

NCBI Gene ID: 55184

neXtProt AC: NX_Q9NVP4

UniProt: Q9NVP4
Chr Location

20p11.23; chr20:18383367-18467281 (-) GRCh38

MGI Vertebrate Homology

Dzank1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DZANK1
Gene Tree

Dzank1

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
2 phenotypes from multigenic genotypes
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

3
Radiation induced

1
Spontaneous

1
Targeted

3
Genomic Mutations

3 involving Dzank1
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

43 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are viable.

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All GO Annotations

7
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

739
Tissues

13
cDNA Data

38
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dzank1

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All Sequences

65
RefSeq

22
UniProt

5
CCDS

CCDS38254.1

Ensembl

ENSMUSG00000037259 (Evidence)
NCBI Gene

241688

			Length	Strain/Species	Flank
genomic	ENSMUSG00000037259	Ensembl Gene Model \| MGI Sequence Detail	56858	C57BL/6J	± kb
transcript	ENSMUST00000163701	Ensembl \| MGI Sequence Detail	6834	Not Applicable
polypeptide	ENSMUSP00000133177	Ensembl \| MGI Sequence Detail	779	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000032269 double zinc ribbon and ankyrin repeat-containing protein 1

(term hierarchy)
InterPro Domains

IPR002110 Ankyrin repeat

IPR036770 Ankyrin repeat-containing domain superfamily

IPR025874 Double zinc ribbon

IPR052481 Double zinc ribbon and ankyrin repeat-containing protein

IPR026876 Fn3 associated repeat
GlyGen

Q8C008 1 site, 1 N-linked glycan (1 site)

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All nucleic 38

cDNA 38

Microarray probesets 2

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MGI:1919971

Summaries

All 41

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 15
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dzank1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr26611	Chr2:144369446-144369457 (-)	-118 bp
Tssr26610	Chr2:144369421-144369432 (-)	-93 bp
Tssr26609	Chr2:144369359-144369370 (-)	-31 bp
Tssr26608	Chr2:144369345-144369352 (-)	-15 bp
Tssr26607	Chr2:144369261-144369344 (-)	31 bp
Tssr26606	Chr2:144316791-144316802 (-)	52,537 bp
Tssr26605	Chr2:144316349-144316359 (-)	52,980 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24