Dis3l MGI Mouse Gene Detail - MGI:2143272 - DIS3 like exosome 3'-5' exoribonuclease

Symbol

Dis3l
Name

DIS3 like exosome 3'-5' exoribonuclease

Feature Type

protein coding gene
IDs

MGI:2143272
NCBI Gene: 213550
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr9:64214038-64248570 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 34.62 cM
Mapping Data

1 experiment

SNPs within 2kb

913 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2143272	protein coding gene	Chr9:64214038-64248707 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0034941	protein coding gene	Chr9:63974700-64009618 (-)
A/J	MGP_AJ_G0034921	protein coding gene	Chr9:61828736-61865484 (-)
AKR/J	MGP_AKRJ_G0034851	protein coding gene	Chr9:63267228-63302111 (-)
BALB/cJ	MGP_BALBcJ_G0034914	protein coding gene	Chr9:61552921-61589130 (-)
C3H/HeJ	MGP_C3HHeJ_G0034624	protein coding gene	Chr9:63793797-63833109 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0035433	protein coding gene	Chr9:65717078-65755953 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032344	protein coding gene	Chr9:61470607-61505170 (-)
CAST/EiJ	MGP_CASTEiJ_G0033945	protein coding gene	Chr9:63956360-63994391 (-)
CBA/J	MGP_CBAJ_G0034595	protein coding gene	Chr9:67970575-68016823 (-)
DBA/2J	MGP_DBA2J_G0034754	protein coding gene	Chr9:61610971-61646864 (-)
FVB/NJ	MGP_FVBNJ_G0034696	protein coding gene	Chr9:60911663-60947089 (-)
LP/J	MGP_LPJ_G0034837	protein coding gene	Chr9:64253934-64289065 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034738	protein coding gene	Chr9:69277141-69311978 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035455	protein coding gene	Chr9:63377066-63416914 (-)
PWK/PhJ	MGP_PWKPhJ_G0033649	protein coding gene	Chr9:61766637-61801141 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0033483	protein coding gene	Chr9:63657335-63692400 (-)
WSB/EiJ	MGP_WSBEiJ_G0034058	protein coding gene	Chr9:63268929-63310075 (-)

Human Ortholog

DIS3L, DIS3 like exosome 3'-5' exoribonuclease

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DIS3L, DIS3 like exosome 3'-5' exoribonuclease
Synonyms

DIS3L1
Links

HGNC:28698

NCBI Gene ID: 115752

neXtProt AC: NX_Q8TF46

UniProt: Q8TF46
Chr Location

15q22.31; chr15:66293217-66333898 (+) GRCh38

MGI Vertebrate Homology

Dis3l stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DIS3L
Gene Tree

Dis3l

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

2
Genomic Mutations

1 involving Dis3l
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

47 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

26
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

42

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dis3l

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All Sequences

66
RefSeq

14
UniProt

3
CCDS

CCDS23280.1, CCDS52832.1

Ensembl

ENSMUSG00000032396 (Evidence)
NCBI Gene

213550

			Length	Strain/Species	Flank
genomic	ENSMUSG00000032396	Ensembl Gene Model \| MGI Sequence Detail	34533	C57BL/6J	± kb
transcript	ENSMUST00000168844	Ensembl \| MGI Sequence Detail	3575	Not Applicable
polypeptide	ENSMUSP00000129772	Ensembl \| MGI Sequence Detail	1053	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000006492 DIS3-like exonuclease 1

(term hierarchy)
EC

3.1.13.1
InterPro Domains

IPR041505 Dis3-like cold-shock domain 2

IPR033770 Exosome complex exonuclease RRP44, S1 domain

IPR012340 Nucleic acid-binding, OB-fold

IPR001900 Ribonuclease II/R

IPR022966 Ribonuclease II/R, conserved site

IPR050180 RNR Ribonuclease

IPR033771 Rrp44-like cold shock domain

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All nucleic 42

cDNA 42

Microarray probesets 3

Summaries

All 34

Gene Ontology 7

Phenotypes 8
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:354575 Wang X, et al., Loss of DIS3L in the initial segment is dispensable for sperm maturation in the epididymis and male fertility. Reprod Biol. 2024 Sep;24(3):100914

TSS for Dis3l:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr90148	Chr9:64248574-64248593 (-)	-14 bp
Tssr90147	Chr9:64248427-64248510 (-)	101 bp
Tssr90146	Chr9:64248301-64248320 (-)	259 bp
Tssr90145	Chr9:64248265-64248276 (-)	299 bp
Tssr90144	Chr9:64248083-64248104 (-)	476 bp
Tssr90143	Chr9:64214089-64214093 (-)	34,479 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24