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Slitrk6 Gene Detail
Summary
  • Symbol
    Slitrk6
  • Name
    SLIT and NTRK-like family, member 6
  • Synonyms
    4832410J21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443198
    NCBI Gene: 239250
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:110986012-110992581 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 57.20 cM, cytoband E3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    242 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443198
 protein coding gene Chr14:110984770-110992640 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021642
 protein coding gene Chr14:107678469-107685006 (-)
A/J MGP_AJ_G0021601
 protein coding gene Chr14:103977570-103984121 (-)
AKR/J MGP_AKRJ_G0021577
 protein coding gene Chr14:107057023-107063553 (-)
BALB/cJ MGP_BALBcJ_G0021607
 protein coding gene Chr14:104438493-104445014 (-)
C3H/HeJ MGP_C3HHeJ_G0021385
 protein coding gene Chr14:107118478-107124991 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022046
 protein coding gene Chr14:112081096-112087603 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019586
 protein coding gene Chr14:100365057-100371637 (-)
CAST/EiJ MGP_CASTEiJ_G0020901
 protein coding gene Chr14:104539410-104545932 (-)
CBA/J MGP_CBAJ_G0021353
 protein coding gene Chr14:116106227-116112755 (-)
DBA/2J MGP_DBA2J_G0021476
 protein coding gene Chr14:103560794-103567339 (-)
FVB/NJ MGP_FVBNJ_G0021454
 protein coding gene Chr14:102333298-102339819 (-)
LP/J MGP_LPJ_G0021544
 protein coding gene Chr14:108617543-108624068 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021480
 protein coding gene Chr14:120213010-120219563 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022070
 protein coding gene Chr14:106690344-106696853 (-)
PWK/PhJ MGP_PWKPhJ_G0020645
 protein coding gene Chr14:100501969-100508563 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020483
 protein coding gene Chr14:102736016-102742568 (-)
WSB/EiJ MGP_WSBEiJ_G0020955
 protein coding gene Chr14:107342065-107348582 (-)



Homology
more
  • Human Ortholog
    SLITRK6, SLIT and NTRK like family member 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLITRK6, SLIT and NTRK like family member 6
  • Synonyms
    DFNMYP
  • Links
    NCBI Gene ID: 84189
    neXtProt AC: NX_Q9H5Y7
    UniProt: Q9H5Y7

  • Chr Location
    13q31.1; chr13:85792790-85806683 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Slitrk6 mouse models; 1 with human SLITRK6 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 1 allele in 2 genetic backgrounds
    4 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous deficient mice show pronounced reduction in cochlear innervation. Innervation to the posterior crista is variably impaired and a there is a loss of neurons in the spiral and vestibular ganglia. Retinas exhibit delayed synaptogenesis and myopia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    9
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    974
  • Tissues
    129
  • cDNA Data
    18
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000045871 Ensembl Gene Model | MGI Sequence Detail 6570 C57BL/6J ±  kb
    transcript ENSMUST00000078386 Ensembl | MGI Sequence Detail 4240 Not Applicable  
    polypeptide ENSMUSP00000077492 Ensembl | MGI Sequence Detail 840 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 18
      Primer pair 2
      Other 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 16
      Diseases 2
      Gene Ontology 9
      Phenotypes 9
    • Earliest
      J:67314 Roix J, et al., Molecular and functional mapping of the piebald deletion complex on mouse chromosome 14. Genetics. 2001 Feb;157(2):803-15
    • Latest
      J:348363 Matsumoto Y, et al., Slitrk4 is required for the development of inhibitory neurons in the fear memory circuit of the lateral amygdala. Front Mol Neurosci. 2024;17:1386924
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory