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Sh3rf3 Gene Detail
Summary
  • Symbol
    Sh3rf3
  • Name
    SH3 domain containing ring finger 3
  • Synonyms
    4831416G18Rik, Sh3md4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444637
    NCBI Gene: 237353
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:58649181-58974738 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 29.41 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    10507 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444637
 protein coding gene Chr10:58649181-58974738 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017252
 protein coding gene Chr10:57947077-58281459 (+)
A/J MGP_AJ_G0017229
 protein coding gene Chr10:56261028-56586734 (+)
AKR/J MGP_AKRJ_G0017188
 protein coding gene Chr10:57723880-58047946 (+)
BALB/cJ MGP_BALBcJ_G0017190
 protein coding gene Chr10:56336583-56659056 (+)
C3H/HeJ MGP_C3HHeJ_G0017013
 protein coding gene Chr10:57630764-57976014 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017648
 protein coding gene Chr10:60037995-60382143 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015339
 protein coding gene Chr10:53322559-53637824 (+)
CAST/EiJ MGP_CASTEiJ_G0016584
 protein coding gene Chr10:57539065-57887720 (+)
CBA/J MGP_CBAJ_G0016985
 protein coding gene Chr10:62195625-62534667 (+)
DBA/2J MGP_DBA2J_G0017090
 protein coding gene Chr10:55579084-55902799 (+)
FVB/NJ MGP_FVBNJ_G0017084
 protein coding gene Chr10:54816698-55132513 (+)
LP/J MGP_LPJ_G0017165
 protein coding gene Chr10:58337851-58672034 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017112
 protein coding gene Chr10:64721959-65073629 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017685
 protein coding gene Chr10:57529505-57857760 (+)
PWK/PhJ MGP_PWKPhJ_G0016367
 protein coding gene Chr10:55367458-55699273 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016150
 protein coding gene Chr10:56881987-57214909 (+)
WSB/EiJ MGP_WSBEiJ_G0016648
 protein coding gene Chr10:57410816-57753910 (+)



Homology
more
  • Human Ortholog
    SH3RF3, SH3 domain containing ring finger 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SH3RF3, SH3 domain containing ring finger 3
  • Synonyms
    POSH2, SH3MD4
  • Links
    NCBI Gene ID: 344558
    neXtProt AC: NX_Q8TEJ3
    UniProt: Q8TEJ3

  • Chr Location
    2q13; chr2:109129205-109504634 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    12
  • cDNA Data
    6
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 237353 NCBI Gene Model | MGI Sequence Detail 325558 C57BL/6J ±  kb
    transcript NM_172788 RefSeq | MGI Sequence Detail 5796 C57BL/6  
    polypeptide Q8C120 UniProt | EBI | MGI Sequence Detail 878 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 6

      Microarray probesets 3
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 12
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory