About   Help   FAQ
Hcar1 Gene Detail
Summary
  • Symbol
    Hcar1
  • Name
    hydrocarboxylic acid receptor 1
  • Synonyms
    Gpr81
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441671
    NCBI Gene: 243270
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:124014802-124018066 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 63.24 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    182 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2441671
 protein coding gene Chr5:124014799-124018083 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030081
 protein coding gene Chr5:127639802-127643087 (-)
A/J MGP_AJ_G0030046
 protein coding gene Chr5:122346456-122349741 (-)
AKR/J MGP_AKRJ_G0029982
 protein coding gene Chr5:126281912-126285198 (-)
BALB/cJ MGP_BALBcJ_G0030057
 protein coding gene Chr5:123674682-123677967 (-)
C3H/HeJ MGP_C3HHeJ_G0029774
 protein coding gene Chr5:126892985-126896272 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030510
 protein coding gene Chr5:132591218-132594502 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027736
 protein coding gene Chr5:116885611-116888892 (-)
CAST/EiJ MGP_CASTEiJ_G0029183
 protein coding gene Chr5:125998440-126001741 (-)
CBA/J MGP_CBAJ_G0029744
 protein coding gene Chr5:137790511-137793795 (-)
DBA/2J MGP_DBA2J_G0029894
 protein coding gene Chr5:122364705-122367989 (-)
FVB/NJ MGP_FVBNJ_G0029850
 protein coding gene Chr5:121395583-121398867 (-)
LP/J MGP_LPJ_G0029983
 protein coding gene Chr5:128187501-128190785 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029881
 protein coding gene Chr5:141407228-141410514 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030551
 protein coding gene Chr5:125885847-125889131 (-)
PWK/PhJ MGP_PWKPhJ_G0028897
 protein coding gene Chr5:121175646-121178944 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028734
 protein coding gene Chr5:123550634-123553919 (-)
WSB/EiJ MGP_WSBEiJ_G0029258
 protein coding gene Chr5:126575362-126578646 (-)



Homology
more
  • Human Ortholog
    HCAR1, hydroxycarboxylic acid receptor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HCAR1, hydroxycarboxylic acid receptor 1
  • Synonyms
    FKSG80, GPR104, GPR81, HCA1, LACR1, TA-GPCR, TAGPCR
  • Links
    NCBI Gene ID: 27198
    neXtProt AC: NX_Q9BXC0
    UniProt: Q9BXC0

  • Chr Location
    12q24.31; chr12:122726076-122730844 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 3 alleles in 3 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display abnormal responses to lactate and impaired retinal vascular development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    711
  • Tissues
    4
  • cDNA Data
    15
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 243270 NCBI Gene Model | MGI Sequence Detail 3265 C57BL/6J ±  kb
    transcript NM_175520 RefSeq | MGI Sequence Detail 3265 C57BL/6  
    polypeptide Q8C131 UniProt | EBI | MGI Sequence Detail 343 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 15
      Primer pair 2
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 2
      Gene Ontology 2
      Phenotypes 25
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:358463 Modaresinejad M, et al., Endoplasmic Reticulum Stress Delays Choroid Development in the HCAR1 Knockout Mouse. Am J Pathol. 2024 Sep 26;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory