Adtrp MGI Mouse Gene Detail - MGI:1924596 - androgen dependent TFPI regulating protein

Symbol

Adtrp
Name

androgen dependent TFPI regulating protein
Synonyms

9530008L14Rik

Feature Type

protein coding gene
IDs

MGI:1924596
NCBI Gene: 109254
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr13:41916621-42001092 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 20.61 cM
Mapping Data

1 experiment

SNPs within 2kb

2226 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924596	protein coding gene	Chr13:41916621-42001160 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020492	protein coding gene	Chr13:40268410-40361241 (-)
A/J	MGP_AJ_G0020446	protein coding gene	Chr13:38930648-39017058 (-)
AKR/J	MGP_AKRJ_G0020424	protein coding gene	Chr13:39998055-40084849 (-)
BALB/cJ	MGP_BALBcJ_G0020442	protein coding gene	Chr13:39123966-39209711 (-)
C3H/HeJ	MGP_C3HHeJ_G0020241	protein coding gene	Chr13:39858147-39945287 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020875	protein coding gene	Chr13:41540360-41633300 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018462	protein coding gene	Chr13:37062017-37143689 (-)
CAST/EiJ	MGP_CASTEiJ_G0019756	protein coding gene	Chr13:39668705-39753510 (-)
CBA/J	MGP_CBAJ_G0020202	protein coding gene	Chr13:43317200-43409121 (-)
DBA/2J	MGP_DBA2J_G0020324	protein coding gene	Chr13:38496182-38581118 (-)
FVB/NJ	MGP_FVBNJ_G0020303	protein coding gene	Chr13:38001410-38086127 (-)
LP/J	MGP_LPJ_G0020399	protein coding gene	Chr13:40523034-40617777 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020332	protein coding gene	Chr13:43270120-43372153 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020918	protein coding gene	Chr13:39632372-39725863 (-)
PWK/PhJ	MGP_PWKPhJ_G0019511	protein coding gene	Chr13:38585906-38672160 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019341	protein coding gene	Chr13:38282041-38373208 (-)
WSB/EiJ	MGP_WSBEiJ_G0019818	protein coding gene	Chr13:39942801-40034517 (-)

Human Ortholog

ADTRP, androgen dependent TFPI regulating protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ADTRP, androgen dependent TFPI regulating protein
Synonyms

AIG1L, C6orf105, dJ413H6.1
Links

HGNC:21214

NCBI Gene ID: 84830

neXtProt AC: NX_Q96IZ2

UniProt: Q96IZ2
Chr Location

6p24.1; chr6:11712054-11807046 (-) GRCh38

MGI Vertebrate Homology

Adtrp stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ADTRP
Gene Tree

Adtrp

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Phenotype Summary

20 phenotypes from 3 alleles in 3 genetic backgrounds
3 phenotypes from multigenic genotypes
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

4
Targeted

3
Genomic Mutations

1 involving Adtrp
Incidental Mutations

APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for one null allele display increased pre-/peri-/neonatal death and vascular abnormalities. Mice homozygous for a second null allele are viable with abnormal hydrolysis of fatty acid esters of hydroxy fatty acids.

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All GO Annotations

19
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

26
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase adtrp

ZFIN adtrp1

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All Sequences

57
RefSeq

11
UniProt

6
CCDS

CCDS36642.1, CCDS49250.1

Ensembl

ENSMUSG00000058022 (Evidence)
NCBI Gene

109254

			Length	Strain/Species	Flank
genomic	109254	NCBI Gene Model \| MGI Sequence Detail	84472	C57BL/6J	± kb
transcript	NM_001145875	RefSeq \| MGI Sequence Detail	2519	C57BL/6
polypeptide	Q8C138	UniProt \| EBI \| MGI Sequence Detail	230	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000032549 androgen-dependent TFPI-regulating protein

(term hierarchy)
EC

3.1.-.-
InterPro Domains

IPR006838 ADTRP/AIG1

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All nucleic 26

cDNA 26

Microarray probesets 3

Summaries

All 34

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 12
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Adtrp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr122225	Chr13:42001102-42001118 (-)	-18 bp
Tssr122224	Chr13:42001075-42001101 (-)	4 bp
Tssr122223	Chr13:42001060-42001074 (-)	25 bp
Tssr122222	Chr13:42001023-42001037 (-)	62 bp
Tssr122221	Chr13:42000997-42001008 (-)	89 bp
Tssr122220	Chr13:42000958-42000966 (-)	130 bp
Tssr122219	Chr13:41982555-41982583 (-)	18,523 bp
Tssr122218	Chr13:41981944-41981951 (-)	19,144 bp
Tssr122217	Chr13:41981894-41981920 (-)	19,185 bp
Tssr122216	Chr13:41981813-41981878 (-)	19,246 bp
Tssr122215	Chr13:41981790-41981801 (-)	19,296 bp
Tssr122214	Chr13:41954145-41954156 (-)	46,941 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24