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Clec2h Gene Detail
Summary
  • Symbol
    Clec2h
  • Name
    C-type lectin domain family 2, member h
  • Synonyms
    Clrf
  • Feature Type
    protein coding gene
  • IDs
    MGI:2136934
    NCBI Gene: 94071
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:128639348-128654337 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 63.07 cM, cytoband F3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    623 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2136934
 protein coding gene Chr6:128639348-128654337 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031333
 protein coding gene Chr6:132295672-132311805 (+)
A/J MGP_AJ_G0031304
 protein coding gene Chr6:127226252-127241892 (+)
AKR/J MGP_AKRJ_G0031231
 protein coding gene Chr6:130647852-130664584 (+)
BALB/cJ MGP_BALBcJ_G0031311
 protein coding gene Chr6:126820851-126835150 (+)
C3H/HeJ MGP_C3HHeJ_G0031035
 protein coding gene Chr6:130818281-130835264 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031768
 protein coding gene Chr6:135737521-135754092 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028913
 protein coding gene Chr6:124545324-124553562 (+)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0030996
 protein coding gene Chr6:141003016-141020550 (+)
DBA/2J MGP_DBA2J_G0031150
 protein coding gene Chr6:126137286-126151286 (+)
FVB/NJ MGP_FVBNJ_G0031100
 protein coding gene Chr6:125039989-125054408 (+)
LP/J MGP_LPJ_G0031232
 protein coding gene Chr6:132442955-132465060 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031138
 protein coding gene Chr6:144822665-144836622 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031801
 protein coding gene Chr6:130665407-130680821 (+)
PWK/PhJ MGP_PWKPhJ_G0030129
 protein coding gene Chr6:124414769-124437673 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029957
 protein coding gene Chr6:128788675-128802016 (+)
WSB/EiJ MGP_WSBEiJ_G0030501
 protein coding gene Chr6:131069445-131084439 (+)



Homology
more
  • Human Ortholog
    CLEC2D, C-type lectin domain family 2 member D
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLEC2D, C-type lectin domain family 2 member D
  • Synonyms
    CLAX, LLT1, OCIL
  • Links
    NCBI Gene ID: 29121
    neXtProt AC: NX_Q9UHP7
    UniProt: Q9UHP7

  • Chr Location
    12p13.31; chr12:9664969-9699553 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 1 allele in 1 genetic background
    11 phenotypes from multigenic genotypes
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit glomerular and tubular lesions, immunoglobulin renal deposits, abdominal and ectopic lipid accumulation, and kidney inflammation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 94071 NCBI Gene Model | MGI Sequence Detail 14990 C57BL/6J ±  kb
    transcript NM_053165 RefSeq | MGI Sequence Detail 2160 C57BL/6  
    polypeptide Q8C1T8 UniProt | EBI | MGI Sequence Detail 218 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 16

      Microarray probesets 4
    References
    more
    • Summaries
      All 22
      Gene Ontology 4
      Phenotypes 2
    • Earliest
      J:69859 Plougastel B, et al., Cloning of Clr, a new family of lectin-like genes localized between mouse Nkrp1a and Cd69. Immunogenetics. 2001 Apr;53(3):209-14
    • Latest
      J:322835 Zein HS, et al., Clr-f expression regulates kidney immune and metabolic homeostasis. Sci Rep. 2022 Mar 22;12(1):4834
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory