Vash1 MGI Mouse Gene Detail - MGI:2442543

Symbol

Vash1
Name

vasohibin 1
Synonyms

D930046M13Rik, G630009D10Rik

Feature Type

protein coding gene
IDs

MGI:2442543
NCBI Gene: 238328
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr12:86725474-86738865 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 40.84 cM
Mapping Data

2 experiments

SNPs within 2kb

475 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442543	protein coding gene	Chr12:86725474-86742462 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019971	protein coding gene	Chr12:87537889-87552825 (+)
A/J	MGP_AJ_G0019928	protein coding gene	Chr12:84206454-84219851 (+)
AKR/J	MGP_AKRJ_G0019904	protein coding gene	Chr12:86492472-86505792 (+)
BALB/cJ	MGP_BALBcJ_G0019908	protein coding gene	Chr12:84548413-84562174 (+)
C3H/HeJ	MGP_C3HHeJ_G0019714	protein coding gene	Chr12:86970565-86985321 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020359	protein coding gene	Chr12:90051804-90065184 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017977	protein coding gene	Chr12:81092163-81105543 (+)
CAST/EiJ	MGP_CASTEiJ_G0019264	protein coding gene	Chr12:81974944-81988222 (+)
CBA/J	MGP_CBAJ_G0019685	protein coding gene	Chr12:93514726-93528004 (+)
DBA/2J	MGP_DBA2J_G0019799	protein coding gene	Chr12:83709138-83722631 (+)
FVB/NJ	MGP_FVBNJ_G0019786	protein coding gene	Chr12:82689640-82703199 (+)
LP/J	MGP_LPJ_G0019873	protein coding gene	Chr12:87409889-87424533 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019825	protein coding gene	Chr12:96278718-96292056 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020392	protein coding gene	Chr12:86116344-86131234 (+)
PWK/PhJ	MGP_PWKPhJ_G0019027	protein coding gene	Chr12:78254956-78269773 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018823	protein coding gene	Chr12:80608675-80623488 (+)
WSB/EiJ	MGP_WSBEiJ_G0019316	protein coding gene	Chr12:86858250-86872456 (+)

Human Ortholog

VASH1, vasohibin 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

VASH1, vasohibin 1
Synonyms

KIAA1036, TTCP 1
Links

HGNC:19964

NCBI Gene ID: 22846

neXtProt AC: NX_Q7L8A9

UniProt: Q7L8A9
Chr Location

14q24.3; chr14:76761468-76783015 (+) GRCh38

MGI Vertebrate Homology

Vash1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: VASH1
Gene Tree

Vash1

Diseases

2 with human VASH1 associations

				Human Disease	Mouse Models
				liver cirrhosis IDs liver cirrhosis DOID:5082 EFO:0001422 ICD10CM:K74.60 MESH:D008103 NCI:C2951 UMLS_CUI:C0023890
				portal hypertension IDs portal hypertension DOID:10762 ICD10CM:K76.6 ICD9CM:572.3 MESH:D006975 NCI:C3119 UMLS_CUI:C0020541

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

1
Targeted

3
Transgenic

1
Genomic Mutations

1 involving Vash1
Incidental Mutations

APF
Find Mice (IMSR)

20 strains or lines available

Homozygous null mice have defects in terminating angiogenesis that occurs near wounds.

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All GO Annotations

32
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

773
Tissues

20
cDNA Data

38
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase vash1

ZFIN vash1

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All Sequences

37
RefSeq

4
UniProt

3
CCDS

CCDS49118.1

Ensembl

ENSMUSG00000021256 (Evidence)
NCBI Gene

238328

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021256	Ensembl Gene Model \| MGI Sequence Detail	13392	C57BL/6J	± kb
transcript	ENSMUST00000021681	Ensembl \| MGI Sequence Detail	2599	Not Applicable
polypeptide	ENSMUSP00000021681	Ensembl \| MGI Sequence Detail	375	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000017260 tubulinyl-Tyr carboxypeptidase 1

(term hierarchy)
EC

3.4.17.17
InterPro Domains

IPR028131 Tubulinyl-Tyr carboxypeptidase

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All nucleic 40

cDNA 39

Primer pair 1

Microarray probesets 3

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MGI:2144886

Summaries

All 52

Developmental Gene Expression 4

Gene Ontology 13

Phenotypes 17
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Vash1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114467	Chr12:86725249-86725272 (+)	-213 bp
Tssr114468	Chr12:86725305-86725322 (+)	-160 bp
Tssr114469	Chr12:86725459-86725570 (+)	41 bp
Tssr114470	Chr12:86725647-86725660 (+)	180 bp
Tssr114471	Chr12:86726224-86726235 (+)	756 bp
Tssr114472	Chr12:86726783-86726810 (+)	1,323 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24