Suco MGI Mouse Gene Detail - MGI:2138346 - SUN domain containing ossification factor

Symbol

Suco
Name

SUN domain containing ossification factor
Synonyms

AI848100, Opt, osteopotentia

Feature Type

protein coding gene
IDs

MGI:2138346
NCBI Gene: 226551
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr1:161643683-161704251 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 69.95 cM
Mapping Data

2 experiments

SNPs within 2kb

1130 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2138346	protein coding gene	Chr1:161643681-161704506 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016655	protein coding gene	Chr1:167125430-167186705 (-)
A/J	MGP_AJ_G0016636	protein coding gene	Chr1:160318112-160380448 (-)
AKR/J	MGP_AKRJ_G0016602	protein coding gene	Chr1:165189756-165251483 (-)
BALB/cJ	MGP_BALBcJ_G0016597	protein coding gene	Chr1:160868294-160929013 (-)
C3H/HeJ	MGP_C3HHeJ_G0016421	protein coding gene	Chr1:165397014-165459293 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017058	protein coding gene	Chr1:172770545-172837636 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014767	protein coding gene	Chr1:152408725-152471631 (-)
CAST/EiJ	MGP_CASTEiJ_G0016001	protein coding gene	Chr1:165034717-165098331 (-)
CBA/J	MGP_CBAJ_G0016396	protein coding gene	Chr1:178912665-178982537 (-)
DBA/2J	MGP_DBA2J_G0016502	protein coding gene	Chr1:159283989-159346726 (-)
FVB/NJ	MGP_FVBNJ_G0016500	protein coding gene	Chr1:157692718-157753478 (-)
LP/J	MGP_LPJ_G0016573	protein coding gene	Chr1:168230081-168301869 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016525	protein coding gene	Chr1:186431848-186521861 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017094	protein coding gene	Chr1:165035998-165099744 (-)
PWK/PhJ	MGP_PWKPhJ_G0015787	protein coding gene	Chr1:158460812-158522897 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015574	protein coding gene	Chr1:163917225-163977806 (-)
WSB/EiJ	MGP_WSBEiJ_G0016063	protein coding gene	Chr1:165202130-165264041 (-)

Human Ortholog

SUCO, SUN domain containing ossification factor

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SUCO, SUN domain containing ossification factor
Synonyms

C1orf9, CH1, OPT, SLP1
Links

HGNC:1240

NCBI Gene ID: 51430

neXtProt AC: NX_Q9UBS9

UniProt: Q9UBS9
Chr Location

1q24.3; chr1:172532349-172611833 (+) GRCh38

MGI Vertebrate Homology

Suco stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SUCO
Gene Tree

Suco

Diseases

1 with Suco mouse models

Human Disease

Mouse Models

osteogenesis imperfecta type 5

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

47 phenotypes from 2 alleles in 3 genetic backgrounds
3 images
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

8
Targeted

2
Genomic Mutations

2 involving Suco
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

49 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a mutation in this gene display background strain-dependent neonatal and postnatal lethality, and impaired osteoblast differentiation resulting in impaired bone formation, brittle bones, and impaired fracture repair.

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All GO Annotations

10
GO References

4

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

87
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase suco

ZFIN suco

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All Sequences

69
RefSeq

21
UniProt

4
CCDS

CCDS48415.1

Ensembl

ENSMUSG00000040297 (Evidence)
NCBI Gene

226551

			Length	Strain/Species	Flank
genomic	ENSMUSG00000040297	Ensembl Gene Model \| MGI Sequence Detail	60569	C57BL/6J	± kb
transcript	ENSMUST00000048377	Ensembl \| MGI Sequence Detail	6327	Not Applicable
polypeptide	ENSMUSP00000044815	Ensembl \| MGI Sequence Detail	1254	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000032354 SUN domain-containing ossification factor

(term hierarchy)
InterPro Domains

IPR008979 Galactose-binding-like domain superfamily

IPR012919 SUN domain

IPR045120 SUN domain-containing Suco/Slp1-like
GlyGen

Q8C341 12 sites, 12 N-linked glycans (11 sites), 1 O-linked glycan (1 site)

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All nucleic 87

cDNA 87

Microarray probesets 6

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MGI:2138413

Summaries

All 37

Developmental Gene Expression 1

Diseases 1

Gene Ontology 4

Phenotypes 13
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Suco:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr14604	Chr1:161704403-161704423 (-)	-162 bp
Tssr14603	Chr1:161704349-161704390 (-)	-119 bp
Tssr14602	Chr1:161704316-161704328 (-)	-71 bp
Tssr14601	Chr1:161704225-161704251 (-)	13 bp
Tssr14600	Chr1:161704179-161704216 (-)	53 bp
Tssr14599	Chr1:161704157-161704176 (-)	84 bp
Tssr14598	Chr1:161694679-161694684 (-)	9,569 bp
Tssr14597	Chr1:161683119-161683130 (-)	21,126 bp
Tssr14596	Chr1:161680351-161680355 (-)	23,898 bp
Tssr14595	Chr1:161662065-161662079 (-)	42,179 bp
Tssr14594	Chr1:161644275-161644278 (-)	59,974 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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