Adgra1 MGI Mouse Gene Detail - MGI:1277167 - adhesion G protein-coupled receptor A1

Symbol

Adgra1
Name

adhesion G protein-coupled receptor A1
Synonyms

2900059M17Rik, D7Ertd680e, Gpr123

Feature Type

protein coding gene
IDs

MGI:1277167
NCBI Gene: 52389
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr7:139414090-139458004 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 84.89 cM
Mapping Data

3 experiments

SNPs within 2kb

1438 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1277167	protein coding gene	Chr7:139414014-139458004 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033153	protein coding gene	Chr7:144906396-144951170 (+)
A/J	MGP_AJ_G0033135	protein coding gene	Chr7:140790640-140834457 (+)
AKR/J	MGP_AKRJ_G0033067	protein coding gene	Chr7:144614447-144660980 (+)
BALB/cJ	MGP_BALBcJ_G0033136	protein coding gene	Chr7:140527610-140572891 (+)
C3H/HeJ	MGP_C3HHeJ_G0032850	protein coding gene	Chr7:144419545-144462973 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033647	protein coding gene	Chr7:150241049-150292822 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030620	protein coding gene	Chr7:141914702-141957747 (+)
CAST/EiJ	MGP_CASTEiJ_G0032180	protein coding gene	Chr7:136714803-136766652 (+)
CBA/J	MGP_CBAJ_G0032823	protein coding gene	Chr7:155310621-155362228 (+)
DBA/2J	MGP_DBA2J_G0032975	protein coding gene	Chr7:138743851-138787674 (+)
FVB/NJ	MGP_FVBNJ_G0032928	protein coding gene	Chr7:138627338-138672390 (+)
LP/J	MGP_LPJ_G0033069	protein coding gene	Chr7:146442599-146486960 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032960	protein coding gene	Chr7:155975791-156025120 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033667	protein coding gene	Chr7:143617049-143666553 (+)
PWK/PhJ	MGP_PWKPhJ_G0031886	protein coding gene	Chr7:131930553-131978345 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031731	protein coding gene	Chr7:130435527-130485922 (+)
WSB/EiJ	MGP_WSBEiJ_G0032291	protein coding gene	Chr7:144516296-144559337 (+)

Human Ortholog

ADGRA1, adhesion G protein-coupled receptor A1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ADGRA1, adhesion G protein-coupled receptor A1
Synonyms

GPR123
Links

HGNC:13838

NCBI Gene ID: 84435

neXtProt AC: NX_Q86SQ6

UniProt: Q86SQ6
Chr Location

10q26.3; chr10:133087924-133131675 (+) GRCh38

MGI Vertebrate Homology

Adgra1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ADGRA1
Gene Tree

Adgra1

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Phenotype Summary

17 phenotypes from 3 alleles in 3 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

2
Radiation induced

1
Targeted

5
Genomic Mutations

1 involving Adgra1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

42 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit increased energy expenditure, adaptive thermogenesis, and activity of thyroid gland.

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All GO Annotations

12
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

747
Tissues

25
cDNA Data

19
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN adgra1a

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All Sequences

47
RefSeq

4
UniProt

5
CCDS

CCDS40171.1

Ensembl

ENSMUSG00000025475 (Evidence)
NCBI Gene

52389

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025475	Ensembl Gene Model \| MGI Sequence Detail	43915	C57BL/6J	± kb
transcript	ENSMUST00000026548	Ensembl \| MGI Sequence Detail	4758	Not Applicable
polypeptide	ENSMUSP00000026548	Ensembl \| MGI Sequence Detail	578	Not Applicable

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UniProt

5 Sequences
InterPro Domains

IPR051963 Adhesion G protein-coupled receptor A

IPR017981 GPCR, family 2-like, 7TM

IPR000832 GPCR, family 2, secretin-like

IPR017983 GPCR, family 2, secretin-like, conserved site

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All nucleic 21

cDNA 19

Primer pair 2

Microarray probesets 4

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MGI:1924702

Summaries

All 42

Developmental Gene Expression 6

Gene Ontology 4

Phenotypes 11
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Adgra1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr69733	Chr7:139414007-139414018 (+)	-77 bp
Tssr69734	Chr7:139414064-139414083 (+)	-16 bp
Tssr69735	Chr7:139414105-139414117 (+)	21 bp
Tssr69736	Chr7:139414118-139414134 (+)	36 bp
Tssr69737	Chr7:139414162-139414181 (+)	82 bp
Tssr69738	Chr7:139414191-139414201 (+)	106 bp
Tssr69739	Chr7:139414222-139414234 (+)	138 bp
Tssr69740	Chr7:139414236-139414268 (+)	162 bp
Tssr69741	Chr7:139414271-139414286 (+)	189 bp
Tssr69742	Chr7:139414346-139414356 (+)	261 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24