Rad51ap1 MGI Mouse Gene Detail - MGI:1098224

Symbol

Rad51ap1
Name

RAD51 associated protein 1
Synonyms

2510006L10Rik, RAB22

Feature Type

protein coding gene
IDs

MGI:1098224
NCBI Gene: 19362
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr6:126900378-126916664 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 61.92 cM
Mapping Data

1 experiment

SNPs within 2kb

523 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1098224	protein coding gene	Chr6:126900013-126916664 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0031308	protein coding gene	Chr6:130397809-130415557 (-)
A/J	MGP_AJ_G0031279	protein coding gene	Chr6:125432402-125463979 (-)
AKR/J	MGP_AKRJ_G0031207	protein coding gene	Chr6:128832167-128850421 (-)
BALB/cJ	MGP_BALBcJ_G0031286	protein coding gene	Chr6:125007207-125025857 (-)
C3H/HeJ	MGP_C3HHeJ_G0031010	protein coding gene	Chr6:128954547-128976204 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031743	protein coding gene	Chr6:133803559-133820048 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028891	protein coding gene	Chr6:122617899-122634337 (-)
CAST/EiJ	MGP_CASTEiJ_G0030391	protein coding gene	Chr6:129150745-129167246 (-)
CBA/J	MGP_CBAJ_G0030971	protein coding gene	Chr6:138932737-138956449 (-)
DBA/2J	MGP_DBA2J_G0031127	protein coding gene	Chr6:124331984-124349258 (-)
FVB/NJ	MGP_FVBNJ_G0031076	protein coding gene	Chr6:123261288-123278296 (-)
LP/J	MGP_LPJ_G0031207	protein coding gene	Chr6:130512610-130531899 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031115	protein coding gene	Chr6:142905837-142929943 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031778	protein coding gene	Chr6:128789290-128809918 (-)
PWK/PhJ	MGP_PWKPhJ_G0030106	protein coding gene	Chr6:122595029-122616571 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0029935	protein coding gene	Chr6:126861664-126878275 (-)
WSB/EiJ	MGP_WSBEiJ_G0030476	protein coding gene	Chr6:129153785-129170372 (-)

Human Ortholog

RAD51AP1, RAD51 associated protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RAD51AP1, RAD51 associated protein 1
Synonyms

PIR51
Links

HGNC:16956

NCBI Gene ID: 10635

neXtProt AC: NX_Q96B01

UniProt: Q96B01
Chr Location

12p13.32; chr12:4538798-4560047 (+) GRCh38

MGI Vertebrate Homology

Rad51ap1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RAD51AP1
Gene Tree

Rad51ap1

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

1
Gene trapped

6
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

38
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

793
Tissues

17
cDNA Data

50
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rad51ap1

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All Sequences

60
RefSeq

10
UniProt

5
CCDS

CCDS39644.1, CCDS85161.1

Ensembl

ENSMUSG00000030346 (Evidence)
NCBI Gene

19362

			Length	Strain/Species	Flank
genomic	19362	NCBI Gene Model \| MGI Sequence Detail	16287	C57BL/6J	± kb
transcript	NM_009013	RefSeq \| MGI Sequence Detail	1884	ZRU/MplStud
polypeptide	Q8C551	UniProt \| EBI \| MGI Sequence Detail	337	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000013673 RAD51-associated protein 1

(term hierarchy)
InterPro Domains

IPR052003 Homologous Recombination DNA-Binding Protein

IPR031419 RAD51 interacting motif

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All nucleic 53

cDNA 51

Primer pair 2

Microarray probesets 6

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MGI:2148250

Summaries

All 44

Developmental Gene Expression 5

Gene Ontology 7

Phenotypes 15
Earliest

J:41499 Mizuta R, et al., RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with the RAD51 protein. Proc Natl Acad Sci U S A. 1997 Jun 24;94(13):6927-32
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rad51ap1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr63352	Chr6:126916487-126916567 (-)	137 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24