Inpp5k MGI Mouse Gene Detail - MGI:1194899 - inositol polyphosphate 5-phosphatase K

Symbol

Inpp5k
Name

inositol polyphosphate 5-phosphatase K
Synonyms

C62, PI-5-phosphatase related, Pps, putative PI-5-phosphatase

Feature Type

protein coding gene
IDs

MGI:1194899
NCBI Gene: 19062
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr11:75521814-75539697 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 45.92 cM
Mapping Data

2 experiments

SNPs within 2kb

380 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1194899	protein coding gene	Chr11:75519893-75539697 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018719	protein coding gene	Chr11:76393866-76414487 (+)
A/J	MGP_AJ_G0018685	protein coding gene	Chr11:73548657-73566942 (+)
AKR/J	MGP_AKRJ_G0018655	protein coding gene	Chr11:75775871-75793521 (+)
BALB/cJ	MGP_BALBcJ_G0018659	protein coding gene	Chr11:73928002-73946912 (+)
C3H/HeJ	MGP_C3HHeJ_G0018472	protein coding gene	Chr11:75792158-75812456 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019110	protein coding gene	Chr11:78807004-78827411 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016745	protein coding gene	Chr11:70562169-70579570 (+)
CAST/EiJ	MGP_CASTEiJ_G0018026	protein coding gene	Chr11:76189848-76207342 (+)
CBA/J	MGP_CBAJ_G0018442	protein coding gene	Chr11:82251520-82276927 (+)
DBA/2J	MGP_DBA2J_G0018551	protein coding gene	Chr11:73152348-73170497 (+)
FVB/NJ	MGP_FVBNJ_G0018541	protein coding gene	Chr11:72714831-72733833 (+)
LP/J	MGP_LPJ_G0018622	protein coding gene	Chr11:76976522-76997573 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018567	protein coding gene	Chr11:82796389-82814656 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019150	protein coding gene	Chr11:75990289-76010704 (+)
PWK/PhJ	MGP_PWKPhJ_G0017797	protein coding gene	Chr11:73855045-73877303 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017588	protein coding gene	Chr11:75542380-75562210 (+)
WSB/EiJ	MGP_WSBEiJ_G0018079	protein coding gene	Chr11:75801842-75821778 (+)

Human Ortholog

INPP5K, inositol polyphosphate-5-phosphatase K

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

INPP5K, inositol polyphosphate-5-phosphatase K
Synonyms

MDCCAID, PPS, SKIP
Links

HGNC:33882

NCBI Gene ID: 51763

neXtProt AC: NX_Q9BT40

UniProt: Q9BT40
Chr Location

17p13.3; chr17:1494577-1516742 (-) GRCh38

MGI Vertebrate Homology

Inpp5k stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: INPP5K
Gene Tree

Inpp5k

Diseases

1 with human INPP5K associations

				Human Disease	Mouse Models
				congenital muscular dystrophy with cataracts and intellectual disability IDs congenital muscular dystrophy with cataracts and intellectual disability DOID:0080197 OMIM:617404

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
13 phenotypes from multigenic genotypes
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

6
Targeted

5
Genomic Mutations

3 involving Inpp5k
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

32 strains or lines available

Homozygous disruption of this gene leads to embryonic lethality. Adult heterozygous mutant mice show normal food intake and adiposity but exhibit enhanced glucose homeostasis and insulin sensitivity, increased insulin action in skeletal muscle, and reduced diet-induced obesity.

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All GO Annotations

104
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

94
cDNA Data

83
Literature Summary

3

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase inpp5k

ZFIN inpp5ka, inpp5kb

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All Sequences

53
RefSeq

6
UniProt

5
CCDS

CCDS25053.1

Ensembl

ENSMUSG00000006127 (Evidence)
NCBI Gene

19062

			Length	Strain/Species	Flank
genomic	ENSMUSG00000006127	Ensembl Gene Model \| MGI Sequence Detail	17884	C57BL/6J	± kb
transcript	ENSMUST00000006286	Ensembl \| MGI Sequence Detail	2679	Not Applicable
polypeptide	ENSMUSP00000006286	Ensembl \| MGI Sequence Detail	468	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000009052 inositol polyphosphate 5-phosphatase K

(term hierarchy)
EC

3.1.3.36, 3.1.3.56, 3.1.3.86
InterPro Domains

IPR036691 Endonuclease/exonuclease/phosphatase superfamily

IPR046985 Inositol 5-phosphatase

IPR000300 Inositol polyphosphate-related phosphatase

IPR041611 SKICH domain

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All nucleic 88

Genomic 3

cDNA 85

Microarray probesets 5

Summaries

All 59

Developmental Gene Expression 3

Gene Ontology 10

Phenotypes 21
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:346856 Manzolillo A, et al., Knockdown of INPP5K compromises the differentiation of N2A cells. Front Mol Neurosci. 2024;17:1356343

TSS for Inpp5k:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103007	Chr11:75521585-75521596 (+)	-223 bp
Tssr103008	Chr11:75521600-75521629 (+)	-199 bp
Tssr3577	Chr11:75521631-75521637 (+)	-180 bp
Tssr103009	Chr11:75521641-75521656 (+)	-165 bp
Tssr103010	Chr11:75521658-75521677 (+)	-146 bp
Tssr103011	Chr11:75521774-75521785 (+)	-34 bp
Tssr103012	Chr11:75521800-75521902 (+)	37 bp
Tssr103013	Chr11:75521912-75521926 (+)	105 bp
Tssr103014	Chr11:75527585-75527640 (+)	5,799 bp
Tssr103015	Chr11:75527643-75527674 (+)	5,845 bp
Tssr103016	Chr11:75533383-75533416 (+)	11,586 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24