Rec8 MGI Mouse Gene Detail - MGI:1929645 - REC8 meiotic recombination protein

Symbol

Rec8
Name

REC8 meiotic recombination protein
Synonyms

mrec, Rec8L1

Feature Type

protein coding gene
IDs

MGI:1929645
NCBI Gene: 56739
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr14:55855494-55862852 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 28.19 cM
Mapping Data

4 experiments

SNPs within 2kb

223 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1929645	protein coding gene	Chr14:55855459-55862852 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021356	protein coding gene	Chr14:49659158-49666475 (+)
A/J	MGP_AJ_G0021315	protein coding gene	Chr14:48666930-48674239 (+)
AKR/J	MGP_AKRJ_G0021291	protein coding gene	Chr14:50412764-50420109 (+)
BALB/cJ	MGP_BALBcJ_G0021319	protein coding gene	Chr14:48619614-48634207 (+)
C3H/HeJ	MGP_C3HHeJ_G0021099	protein coding gene	Chr14:50098088-50106360 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021757	protein coding gene	Chr14:52149395-52156702 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019304	protein coding gene	Chr14:47041194-47048321 (+)
CAST/EiJ	MGP_CASTEiJ_G0020618	protein coding gene	Chr14:46361715-46370758 (+)
CBA/J	MGP_CBAJ_G0021066	protein coding gene	Chr14:53710685-53717986 (+)
DBA/2J	MGP_DBA2J_G0021187	protein coding gene	Chr14:48391044-48398393 (+)
FVB/NJ	MGP_FVBNJ_G0021169	protein coding gene	Chr14:47839297-47846619 (+)
LP/J	MGP_LPJ_G0021261	protein coding gene	Chr14:50703779-50713154 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021193	protein coding gene	Chr14:53069358-53076668 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021784	protein coding gene	Chr14:49599738-49607444 (+)
PWK/PhJ	MGP_PWKPhJ_G0020365	protein coding gene	Chr14:44923108-44930534 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020193	protein coding gene	Chr14:45604951-45615783 (+)
WSB/EiJ	MGP_WSBEiJ_G0020671	protein coding gene	Chr14:49886728-49894137 (+)

Human Ortholog

REC8, REC8 meiotic recombination protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

REC8, REC8 meiotic recombination protein
Synonyms

HR21spB, REC8L1, Rec8p
Links

HGNC:16879

NCBI Gene ID: 9985

neXtProt AC: NX_O95072

UniProt: O95072
Chr Location

14q12

MGI Vertebrate Homology

Rec8 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: REC8
Gene Tree

Rec8

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Phenotype Summary

26 phenotypes from 4 alleles in 6 genetic backgrounds
4 phenotypes from multigenic genotypes
35 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

2
Endonuclease-mediated

2
Targeted

6
Genomic Mutations

1 involving Rec8
Incidental Mutations

APF
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice are infertile and exhibit small ovaries and testes. Females show absence of ovarian follicles and abnormal meiosis, while males exhibit abnormal chromosome pairing during meiosis, abnormal synaptonemal complex formation, and arrest of male meiosis.

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All GO Annotations

31
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1026
Tissues

134
cDNA Data

19
Literature Summary

39

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rec8

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All Sequences

42
RefSeq

7
UniProt

1
CCDS

CCDS27120.1

Ensembl

ENSMUSG00000002324 (Evidence)
NCBI Gene

56739

			Length	Strain/Species	Flank
genomic	ENSMUSG00000002324	Ensembl Gene Model \| MGI Sequence Detail	7359	C57BL/6J	± kb
transcript	ENSMUST00000002395	Ensembl \| MGI Sequence Detail	2184	Not Applicable
polypeptide	ENSMUSP00000002395	Ensembl \| MGI Sequence Detail	591	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000013858 meiotic recombination protein REC8

(term hierarchy)
InterPro Domains

IPR039781 Rad21/Rec8-like protein

IPR006909 Rad21/Rec8-like protein, C-terminal, eukaryotic

IPR006910 Rad21/Rec8-like protein, N-terminal

IPR023093 ScpA-like, C-terminal

IPR036390 Winged helix DNA-binding domain superfamily

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All nucleic 24

cDNA 19

Primer pair 5

Microarray probesets 3

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MGI:2145829

Summaries

All 110

Developmental Gene Expression 39

Gene Ontology 16

Phenotypes 35
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:357739 Chotiner JY, et al., TRIP13 localizes to synapsed chromosomes and functions as a dosage-sensitive regulator of meiosis. Elife. 2024 Aug 29;12

TSS for Rec8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125792	Chr14:55855454-55855468 (+)	-33 bp
Tssr125793	Chr14:55855480-55855494 (+)	-7 bp
Tssr125794	Chr14:55855583-55855594 (+)	95 bp
Tssr125795	Chr14:55855595-55855640 (+)	124 bp
Tssr125796	Chr14:55856495-55856520 (+)	1,014 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24