Epc1 MGI Mouse Gene Detail - MGI:1278322 - enhancer of polycomb homolog 1

Symbol

Epc1
Name

enhancer of polycomb homolog 1
Synonyms

2400007E14Rik, 5730566F07Rik, A930032N02Rik

Feature Type

protein coding gene
IDs

MGI:1278322
NCBI Gene: 13831
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr18:6435951-6516108 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 4.48 cM, cytoband A1
Mapping Data

2 experiments

SNPs within 2kb

1718 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1278322	protein coding gene	Chr18:6435951-6516108 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024130	protein coding gene	Chr18:3303416-3387429 (-)
A/J	MGP_AJ_G0024092	protein coding gene	Chr18:3319164-3400055 (-)
AKR/J	MGP_AKRJ_G0024060	protein coding gene	Chr18:3396903-3491274 (-)
BALB/cJ	MGP_BALBcJ_G0024092	protein coding gene	Chr18:3289419-3373247 (-)
C3H/HeJ	MGP_C3HHeJ_G0023858	protein coding gene	Chr18:3308920-3393859 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024537	protein coding gene	Chr18:3546708-3627805 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021976	protein coding gene	Chr18:3068453-3149884 (-)
CAST/EiJ	MGP_CASTEiJ_G0023336	protein coding gene	Chr18:3337908-3417090 (-)
CBA/J	MGP_CBAJ_G0023831	protein coding gene	Chr18:3465612-3549498 (-)
DBA/2J	MGP_DBA2J_G0023959	protein coding gene	Chr18:3204929-3285132 (-)
FVB/NJ	MGP_FVBNJ_G0023925	protein coding gene	Chr18:3204276-3285559 (-)
LP/J	MGP_LPJ_G0024043	protein coding gene	Chr18:3336621-3419845 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023953	protein coding gene	Chr18:3558151-3644131 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024582	protein coding gene	Chr18:3276856-3357412 (-)
PWK/PhJ	MGP_PWKPhJ_G0023081	protein coding gene	Chr18:3239629-3319447 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022892	protein coding gene	Chr18:3552420-3637510 (-)
WSB/EiJ	MGP_WSBEiJ_G0023402	protein coding gene	Chr18:3303733-3385086 (-)

Human Ortholog

EPC1, enhancer of polycomb homolog 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EPC1, enhancer of polycomb homolog 1
Synonyms

Epl1
Links

HGNC:19876

NCBI Gene ID: 80314

neXtProt AC: NX_Q9H2F5

UniProt: Q9H2F5
Chr Location

10p11.22; chr10:32267751-32378798 (-) GRCh38

MGI Vertebrate Homology

Epc1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: EPC1
Gene Tree

Epc1

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

32
Gene trapped

29
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

55 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trap allele die prior to P10 (no time point given) and heterozygous mice exhibit impaired skeletal muscle differentiation.

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All GO Annotations

42
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

863
Tissues

133
cDNA Data

55
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA EPC1

Xenbase epc1

ZFIN epc1b

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All Sequences

60
RefSeq

6
UniProt

5
CCDS

CCDS29041.1, CCDS37726.1, CCDS70868.1

Ensembl

ENSMUSG00000024240 (Evidence)
NCBI Gene

13831

			Length	Strain/Species	Flank
genomic	13831	NCBI Gene Model \| MGI Sequence Detail	80158	C57BL/6J	± kb
transcript	NM_027497	RefSeq \| MGI Sequence Detail	3983	C57BL/6
polypeptide	Q8C9X6	UniProt \| EBI \| MGI Sequence Detail	813	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000007116 enhancer of polycomb homolog 1

(term hierarchy)
InterPro Domains

IPR009607 Enhancer of polycomb, C-terminal

IPR019542 Enhancer of polycomb-like, N-terminal

IPR024943 Enhancer of polycomb protein

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All nucleic 60

cDNA 58

Primer pair 1

Other 1

Microarray probesets 4

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MGI:1916980, MGI:1917905, MGI:1924445

Summaries

All 51

Developmental Gene Expression 6

Gene Ontology 10

Phenotypes 14
Earliest

J:43737 Stankunas K, et al., The enhancer of polycomb gene of Drosophila encodes a chromatin protein conserved in yeast and mammals. Development. 1998 Oct;125(20):4055-66
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Epc1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr152365	Chr18:6516089-6516106 (-)	10 bp
Tssr152364	Chr18:6516067-6516083 (-)	33 bp
Tssr152363	Chr18:6515134-6515140 (-)	971 bp
Tssr152362	Chr18:6510715-6510722 (-)	5,389 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/22/2024 MGI 6.24