Fam161b MGI Mouse Gene Detail - MGI:2443027 - family with sequence similarity 161, member B

Symbol

Fam161b
Name

family with sequence similarity 161, member B
Synonyms

9830169C18Rik

Feature Type

protein coding gene
IDs

MGI:2443027
NCBI Gene: 217705
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr12:84392083-84408607 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 39.17 cM
Mapping Data

2 experiments

SNPs within 2kb

522 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443027	protein coding gene	Chr12:84392083-84408633 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019933	protein coding gene	Chr12:85048950-85065474 (-)
A/J	MGP_AJ_G0019890	protein coding gene	Chr12:81828994-81845516 (-)
AKR/J	MGP_AKRJ_G0019866	protein coding gene	Chr12:84046601-84063879 (-)
BALB/cJ	MGP_BALBcJ_G0019870	protein coding gene	Chr12:82162655-82179179 (-)
C3H/HeJ	MGP_C3HHeJ_G0019676	protein coding gene	Chr12:84510751-84527275 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020321	protein coding gene	Chr12:87489849-87510547 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017939	protein coding gene	Chr12:78732199-78748132 (-)
CAST/EiJ	MGP_CASTEiJ_G0019225	protein coding gene	Chr12:79461781-79480328 (-)
CBA/J	MGP_CBAJ_G0019647	protein coding gene	Chr12:90873509-90891921 (-)
DBA/2J	MGP_DBA2J_G0019762	protein coding gene	Chr12:81358090-81374614 (-)
FVB/NJ	MGP_FVBNJ_G0019748	protein coding gene	Chr12:80309697-80326221 (-)
LP/J	MGP_LPJ_G0019834	protein coding gene	Chr12:84926746-84943645 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019787	protein coding gene	Chr12:93785206-93803068 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020355	protein coding gene	Chr12:83641179-83657574 (-)
PWK/PhJ	MGP_PWKPhJ_G0018989	protein coding gene	Chr12:75845254-75862163 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018784	protein coding gene	Chr12:78130254-78146331 (-)
WSB/EiJ	MGP_WSBEiJ_G0019277	protein coding gene	Chr12:84352302-84368800 (-)

Human Ortholog

FAM161B, FAM161 centrosomal protein B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FAM161B, FAM161 centrosomal protein B
Synonyms

c14_5547, C14orf44
Links

HGNC:19854

NCBI Gene ID: 145483

neXtProt AC: NX_Q96MY7

UniProt: Q96MY7
Chr Location

14q24.3; chr14:73922699-73950414 (-) GRCh38

MGI Vertebrate Homology

Fam161b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FAM161B
Gene Tree

Fam161b

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

1
Targeted

2
Genomic Mutations

1 involving Fam161b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

5
GO References

3

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

16

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fam161b

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All Sequences

43
RefSeq

7
UniProt

1
CCDS

CCDS26043.1

Ensembl

ENSMUSG00000021234 (Evidence)
NCBI Gene

217705

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021234	Ensembl Gene Model \| MGI Sequence Detail	16525	C57BL/6J	± kb
transcript	ENSMUST00000065536	Ensembl \| MGI Sequence Detail	3000	Not Applicable
polypeptide	ENSMUSP00000070407	Ensembl \| MGI Sequence Detail	589	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000031837 protein FAM161B

(term hierarchy)
InterPro Domains

IPR051655 FAM161

IPR019579 Protein FAM161A/B

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All nucleic 16

cDNA 16

Microarray probesets 2

Summaries

All 29

Gene Ontology 3

Phenotypes 9
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Fam161b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr116999	Chr12:84408576-84408612 (-)	13 bp
Tssr116998	Chr12:84408556-84408571 (-)	43 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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