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Synpo Gene Detail
Summary
  • Symbol
    Synpo
  • Name
    synaptopodin
  • Synonyms
    9030217H17Rik, 9330140I15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1099446
    NCBI Gene: 104027
  • Alliance
    gene page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:60727045-60793214 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 34.36 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1708 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1099446
 protein coding gene Chr18:60727045-60793241 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024465
 protein coding gene Chr18:60405510-60475939 (-)
A/J MGP_AJ_G0024432
 protein coding gene Chr18:57823216-57890647 (-)
AKR/J MGP_AKRJ_G0024402
 protein coding gene Chr18:59423985-59489970 (-)
BALB/cJ MGP_BALBcJ_G0024431
 protein coding gene Chr18:57956846-58023389 (-)
C3H/HeJ MGP_C3HHeJ_G0024199
 protein coding gene Chr18:59653720-59721745 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024878
 protein coding gene Chr18:62070685-62136770 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022309
 protein coding gene Chr18:57376595-57444633 (-)
CAST/EiJ MGP_CASTEiJ_G0023672
 protein coding gene Chr18:59510704-59582635 (-)
CBA/J MGP_CBAJ_G0024169
 protein coding gene Chr18:64081188-64156936 (-)
DBA/2J MGP_DBA2J_G0024299
 protein coding gene Chr18:57506262-57573084 (-)
FVB/NJ MGP_FVBNJ_G0024265
 protein coding gene Chr18:56900393-56968547 (-)
LP/J MGP_LPJ_G0024382
 protein coding gene Chr18:60266191-60336642 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024294
 protein coding gene Chr18:65714891-65782097 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024925
 protein coding gene Chr18:59606773-59676762 (-)
PWK/PhJ MGP_PWKPhJ_G0023415
 protein coding gene Chr18:57725965-57793332 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023221
 protein coding gene Chr18:59846057-59914360 (-)
WSB/EiJ MGP_WSBEiJ_G0023736
 protein coding gene Chr18:59469747-59537050 (-)



Homology
more
  • Human Ortholog
    SYNPO, synaptopodin
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SYNPO, synaptopodin
  • Synonyms
    SYNPO1
  • Links
    NCBI Gene ID: 11346
    neXtProt AC: NX_Q8N3V7
    UniProt: Q8N3V7

  • Chr Location
    5q33.1; chr5:150586010-150659207 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display abnormalities in telencephalic neurons, reduced long term potentiation, and behavioral abnormalities including hypoactivity, reduced anxiety, and learning deficiencies.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    41
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    937
  • Tissues
    112
  • cDNA Data
    21
  • Literature Summary
    37
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000043079 Ensembl Gene Model | MGI Sequence Detail 66170 C57BL/6J ±  kb
transcript ENSMUST00000130360 Ensembl | MGI Sequence Detail 5159 Not Applicable  
polypeptide ENSMUSP00000115355 Ensembl | MGI Sequence Detail 1100 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000015886 synaptopodin
    (term hierarchy)
  • InterPro Domains
    IPR051976 Synaptopodin domain-containing protein
  • GlyGen
    Q8CC35 17 sites, 4 N-linked glycans (4 sites), 1 O-linked glycan (13 sites)
Molecular
Reagents
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  • All nucleic 22
    cDNA 21
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
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MGI:1924944, MGI:2147341, MGI:2442267
References
more
  • Summaries
    All 98
    Developmental Gene Expression 37
    Gene Ontology 11
    Phenotypes 20
  • Earliest
    J:43510 Mundel P, et al., Synaptopodin: an actin-associated protein in telencephalic dendrites and renal podocytes. J Cell Biol. 1997 Oct 6;139(1):193-204
  • Latest
    J:347016 Inglebert Y, et al., Synaptopodin is required for long-term depression at Schaffer collateral-CA1 synapses. Mol Brain. 2024 Apr 2;17(1):17
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/22/2024
MGI 6.24 		The Jackson Laboratory