Piezo2 MGI Mouse Gene Detail - MGI:1918781 - piezo-type mechanosensitive ion channel component 2

Symbol

Piezo2
Name

piezo-type mechanosensitive ion channel component 2
Synonyms

9030411M15Rik, 9430028L06Rik, Fam38b, Fam38b2, Piezo2

Feature Type

protein coding gene
IDs

MGI:1918781
NCBI Gene: 667742
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr18:63143284-63520254 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 35.95 cM, cytoband D3
Mapping Data

2 experiments

SNPs within 2kb

11960 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918781	protein coding gene	Chr18:63143284-63520787 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024498	protein coding gene	Chr18:62970776-63394565 (-)
A/J	MGP_AJ_G0024465	protein coding gene	Chr18:60288425-60674151 (-)
AKR/J	MGP_AKRJ_G0024435	protein coding gene	Chr18:61947193-62374447 (-)
BALB/cJ	MGP_BALBcJ_G0024464	protein coding gene	Chr18:60430329-60812128 (-)
C3H/HeJ	MGP_C3HHeJ_G0024232	protein coding gene	Chr18:62192935-62591662 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024911	protein coding gene	Chr18:64683701-65110149 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022342	protein coding gene	Chr18:59792319-60149511 (-)
CAST/EiJ	MGP_CASTEiJ_G0023705	protein coding gene	Chr18:62065255-62458505 (-)
CBA/J	MGP_CBAJ_G0024202	protein coding gene	Chr18:66788488-67214756 (-)
DBA/2J	MGP_DBA2J_G0024332	protein coding gene	Chr18:59941625-60330764 (-)
FVB/NJ	MGP_FVBNJ_G0024298	protein coding gene	Chr18:59341075-59721347 (-)
LP/J	MGP_LPJ_G0024416	protein coding gene	Chr18:62859173-63266928 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024327	protein coding gene	Chr18:68309897-68732910 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024958	protein coding gene	Chr18:62161238-62576183 (-)
PWK/PhJ	MGP_PWKPhJ_G0023448	protein coding gene	Chr18:60181346-60561854 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023253	protein coding gene	Chr18:62362504-62753380 (-)
WSB/EiJ	MGP_WSBEiJ_G0023769	protein coding gene	Chr18:62014081-62419068 (-)

Human Ortholog

PIEZO2, piezo type mechanosensitive ion channel component 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PIEZO2, piezo type mechanosensitive ion channel component 2
Synonyms

C18orf30, C18orf58, DA3, DA5, DAIPT, FAM38B, FAM38B2, HsT748, HsT771, MWKS
Links

HGNC:26270

NCBI Gene ID: 63895

neXtProt AC: NX_Q9H5I5

UniProt: Q9H5I5
Chr Location

18p11.22-p11.21; chr18:10666483-11149569 (-) GRCh38

MGI Vertebrate Homology

Piezo2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: PIEZO2
Gene Tree

Piezo2

Diseases

2 with human PIEZO2 associations

				Human Disease	Mouse Models
				distal arthrogryposis type 3 IDs distal arthrogryposis type 3 DOID:0111607 MESH:C537288 OMIM:114300 ORDO:376
				distal arthrogryposis type 5 IDs distal arthrogryposis type 5 DOID:0111608 MESH:C537737 OMIM:108145

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
6 phenotypes from multigenic genotypes
66 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

7
Targeted

6
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

123 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a null allele exhibit impaired injury-induced tactile pain detection.

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All GO Annotations

24
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

724
Tissues

7
cDNA Data

28
Literature Summary

10

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase piezo2

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All Sequences

91
RefSeq

20
UniProt

12
CCDS

CCDS29296.2

Ensembl

ENSMUSG00000041482 (Evidence)
NCBI Gene

667742

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041482	Ensembl Gene Model \| MGI Sequence Detail	376971	C57BL/6J	± kb
transcript	ENSMUST00000047480	Ensembl \| MGI Sequence Detail	10724	Not Applicable
polypeptide	ENSMUSP00000040019	Ensembl \| MGI Sequence Detail	2824	Not Applicable

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UniProt

12 Sequences
Protein Ontology

PR:000032708 piezo-type mechanosensitive ion channel component 2

(term hierarchy)
PDB

6KG7
InterPro Domains

IPR031805 Piezo domain

IPR027272 Piezo family

IPR031334 Piezo non-specific cation channel, R-Ras-binding domain
GlyGen

Q8CD54 4 sites

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All nucleic 30

cDNA 29

Primer pair 1

Microarray probesets 3

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MGI:2442541

Summaries

All 107

Developmental Gene Expression 10

Gene Ontology 9

Phenotypes 66
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:353123 Zhang D, et al., C-LTMRs mediate wet dog shakes via the spinoparabrachial pathway. bioRxiv. 2024 Jun 11;

TSS for Piezo2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr153639	Chr18:63520195-63520260 (-)	26 bp
Tssr5350	Chr18:63520116-63520125 (-)	133 bp
Tssr153638	Chr18:63519582-63519597 (-)	664 bp
Tssr153637	Chr18:63519566-63519578 (-)	682 bp
Tssr153636	Chr18:63220547-63220551 (-)	299,705 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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