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Piwil2 Gene Detail
Summary
  • Symbol
    Piwil2
  • Name
    piwi-like RNA-mediated gene silencing 2
  • Synonyms
    mili, Miwi like
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930036
    NCBI Gene: 57746
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:70609926-70666832 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 36.32 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1464 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1930036
 protein coding gene Chr14:70609926-70674338 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021536
 protein coding gene Chr14:65022033-65080322 (-)
A/J MGP_AJ_G0021495
 protein coding gene Chr14:63639784-63697179 (-)
AKR/J MGP_AKRJ_G0021471
 protein coding gene Chr14:65548104-65608798 (-)
BALB/cJ MGP_BALBcJ_G0021501
 protein coding gene Chr14:63403666-63460128 (-)
C3H/HeJ MGP_C3HHeJ_G0021278
 protein coding gene Chr14:65268001-65324293 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021940
 protein coding gene Chr14:67927458-67991730 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019480
 protein coding gene Chr14:61475367-61532505 (-)
CAST/EiJ MGP_CASTEiJ_G0020795
 protein coding gene Chr14:61852469-61915294 (-)
CBA/J MGP_CBAJ_G0021245
 protein coding gene Chr14:70068810-70131682 (-)
DBA/2J MGP_DBA2J_G0021368
 protein coding gene Chr14:63023301-63081091 (-)
FVB/NJ MGP_FVBNJ_G0021347
 protein coding gene Chr14:62453318-62510001 (-)
LP/J MGP_LPJ_G0021439
 protein coding gene Chr14:66259281-66321016 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021376
 protein coding gene Chr14:68963992-69021833 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021964
 protein coding gene Chr14:64811506-64870558 (-)
PWK/PhJ MGP_PWKPhJ_G0020539
 protein coding gene Chr14:59789323-59848020 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020372
 protein coding gene Chr14:60737206-60796700 (-)
WSB/EiJ MGP_WSBEiJ_G0020848
 protein coding gene Chr14:65119204-65178051 (-)



Homology
more
  • Human Ortholog
    PIWIL2, piwi like RNA-mediated gene silencing 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PIWIL2, piwi like RNA-mediated gene silencing 2
  • Synonyms
    CT80, HILI, mili, PIWIL1L
  • Links
    NCBI Gene ID: 55124
    neXtProt AC: NX_Q8TC59
    UniProt: Q8TC59

  • Chr Location
    8p21.3; chr8:22275316-22357568 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 5 alleles in 5 genetic backgrounds
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased testis weight, azoospermia, and male infertility associated with a complete arrest of spermatogenesis and increased apoptotic cell death during the early prophase of the first meiosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    57
  • GO References
    31
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    884
  • Tissues
    82
  • cDNA Data
    25
  • Literature Summary
    43
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033644 Ensembl Gene Model | MGI Sequence Detail 56907 C57BL/6J ±  kb
    transcript ENSMUST00000048129 Ensembl | MGI Sequence Detail 4916 Not Applicable  
    polypeptide ENSMUSP00000047385 Ensembl | MGI Sequence Detail 971 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 25
      Primer pair 5
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 111
      Developmental Gene Expression 43
      Gene Ontology 31
      Phenotypes 38
    • Earliest
      J:68614 Wang PJ, et al., An abundance of X-linked genes expressed in spermatogonia. Nat Genet. 2001 Apr;27(4):422-6
    • Latest
      J:336533 Gasperini C, et al., Piwil2 (Mili) sustains neurogenesis and prevents cellular senescence in the postnatal hippocampus. EMBO Rep. 2023 Feb 6;24(2):e53801
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory