Txnl1 MGI Mouse Gene Detail - MGI:1860078

Symbol

Txnl1
Name

thioredoxin-like 1
Synonyms

32kDa, TRP32

Feature Type

protein coding gene
IDs

MGI:1860078
NCBI Gene: 53382
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr18:63795872-63825535 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 37.06 cM, cytoband D3
Mapping Data

3 experiments

SNPs within 2kb

679 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1860078	protein coding gene	Chr18:63794165-63841872 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024499	protein coding gene	Chr18:63666800-63697182 (-)
A/J	MGP_AJ_G0024466	protein coding gene	Chr18:60939366-60969999 (-)
AKR/J	MGP_AKRJ_G0024436	protein coding gene	Chr18:62637710-62669328 (-)
BALB/cJ	MGP_BALBcJ_G0024465	protein coding gene	Chr18:61073074-61104754 (-)
C3H/HeJ	MGP_C3HHeJ_G0024233	protein coding gene	Chr18:62857945-62890750 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024912	protein coding gene	Chr18:65393693-65426244 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022343	protein coding gene	Chr18:60401407-60431626 (-)
CAST/EiJ	MGP_CASTEiJ_G0023706	protein coding gene	Chr18:62742278-62773456 (-)
CBA/J	MGP_CBAJ_G0024203	protein coding gene	Chr18:67503273-67538680 (-)
DBA/2J	MGP_DBA2J_G0024333	protein coding gene	Chr18:60599330-60630693 (-)
FVB/NJ	MGP_FVBNJ_G0024299	protein coding gene	Chr18:59980981-60010721 (-)
LP/J	MGP_LPJ_G0024417	protein coding gene	Chr18:63535607-63564853 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024328	protein coding gene	Chr18:69013335-69056912 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024959	protein coding gene	Chr18:62833489-62863489 (-)
PWK/PhJ	MGP_PWKPhJ_G0023449	protein coding gene	Chr18:60803644-60853615 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023254	protein coding gene	Chr18:63014220-63044252 (-)
WSB/EiJ	MGP_WSBEiJ_G0023770	protein coding gene	Chr18:62688442-62718946 (-)

Human Ortholog

TXNL1, thioredoxin like 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TXNL1, thioredoxin like 1
Synonyms

HEL-S-114, TRP32, Txl, TXL-1, TXNL
Links

HGNC:12436

NCBI Gene ID: 9352

neXtProt AC: NX_O43396

UniProt: O43396
Chr Location

18q21.31; chr18:56597209-56651600 (-) GRCh38

MGI Vertebrate Homology

Txnl1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TXNL1
Gene Tree

Txnl1

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

28
Endonuclease-mediated

2
Gene trapped

24
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

8
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

748
Tissues

41
cDNA Data

129
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase txnl1

ZFIN txnl1

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All Sequences

64
RefSeq

3
UniProt

8
CCDS

CCDS29297.1

Ensembl

ENSMUSG00000024583 (Evidence)
NCBI Gene

53382

			Length	Strain/Species	Flank
genomic	53382	NCBI Gene Model \| MGI Sequence Detail	29664	C57BL/6J	± kb
transcript	NM_016792	RefSeq \| MGI Sequence Detail	2558	C57BL/6
polypeptide	Q8CDN6	UniProt \| EBI \| MGI Sequence Detail	289	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000016868 thioredoxin-like protein 1

(term hierarchy)
InterPro Domains

IPR000095 CRIB domain

IPR008979 Galactose-binding-like domain superfamily

IPR010400 PITH domain

IPR037047 PITH domain superfamily

IPR017937 Thioredoxin, conserved site

IPR013766 Thioredoxin domain

IPR036249 Thioredoxin-like superfamily
GlyGen

Q8CDN6 1 site, 1 O-linked glycan (1 site)

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All nucleic 130

cDNA 129

Other 1

Microarray probesets 8

Summaries

All 38

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 11
Earliest

J:62232 Lee KK, et al., Purification, molecular cloning, and characterization of TRP32, a novel thioredoxin-related mammalian protein of 32 kDa [published erratum appears in J Biol Chem 1998 Oct 16;273(42):27755]. J Biol Chem. 1998 Jul 24;273(30):19160-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Txnl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr153650	Chr18:63825491-63825502 (-)	38 bp
Tssr153649	Chr18:63825463-63825487 (-)	60 bp
Tssr153648	Chr18:63825457-63825462 (-)	75 bp
Tssr153647	Chr18:63825412-63825445 (-)	106 bp
Tssr153646	Chr18:63825380-63825409 (-)	140 bp
Tssr153645	Chr18:63825362-63825373 (-)	167 bp
Tssr153644	Chr18:63825350-63825361 (-)	179 bp
Tssr153643	Chr18:63825288-63825299 (-)	241 bp
Tssr153642	Chr18:63815344-63815383 (-)	10,171 bp
Tssr153641	Chr18:63815325-63815336 (-)	10,204 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24