Tab1 MGI Mouse Gene Detail - MGI:1913763 - TGF-beta activated kinase 1/MAP3K7 binding protein 1

Symbol

Tab1
Name

TGF-beta activated kinase 1/MAP3K7 binding protein 1
Synonyms

2310012M03Rik, b2b449Clo, Map3k7ip1, Tak1-binding protein 1

Feature Type

protein coding gene
IDs

MGI:1913763
NCBI Gene: 66513
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr15:80017333-80045908 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 37.85 cM, cytoband E2
Mapping Data

2 experiments

SNPs within 2kb

870 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913763	protein coding gene	Chr15:80017328-80045908 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022094	protein coding gene	Chr15:80449965-80483139 (+)
A/J	MGP_AJ_G0022055	protein coding gene	Chr15:77665139-77694192 (+)
AKR/J	MGP_AKRJ_G0022030	protein coding gene	Chr15:79832486-79861079 (+)
BALB/cJ	MGP_BALBcJ_G0022061	protein coding gene	Chr15:77672849-77701775 (+)
C3H/HeJ	MGP_C3HHeJ_G0021832	protein coding gene	Chr15:79825962-79857440 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022504	protein coding gene	Chr15:83615198-83646639 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020034	protein coding gene	Chr15:74144474-74174627 (+)
CAST/EiJ	MGP_CASTEiJ_G0021353	protein coding gene	Chr15:80542467-80571908 (+)
CBA/J	MGP_CBAJ_G0021797	protein coding gene	Chr15:86267492-86298583 (+)
DBA/2J	MGP_DBA2J_G0021926	protein coding gene	Chr15:77157311-77185876 (+)
FVB/NJ	MGP_FVBNJ_G0021904	protein coding gene	Chr15:76177561-76206314 (+)
LP/J	MGP_LPJ_G0021994	protein coding gene	Chr15:80630612-80662396 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021924	protein coding gene	Chr15:91290261-91319825 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022518	protein coding gene	Chr15:79868830-79898433 (+)
PWK/PhJ	MGP_PWKPhJ_G0021095	protein coding gene	Chr15:77167697-77197062 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020932	protein coding gene	Chr15:79670694-79699678 (+)
WSB/EiJ	MGP_WSBEiJ_G0021405	protein coding gene	Chr15:80273920-80304239 (+)

Human Ortholog

TAB1, TGF-beta activated kinase 1 (MAP3K7) binding protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TAB1, TGF-beta activated kinase 1 (MAP3K7) binding protein 1
Synonyms

3'-Tab1, MAP3K7IP1
Links

HGNC:18157

NCBI Gene ID: 10454

neXtProt AC: NX_Q15750

UniProt: Q15750
Chr Location

22q13.1; chr22:39399778-39437132 (+) GRCh38

MGI Vertebrate Homology

Tab1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TAB1
Gene Tree

Tab1

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References

1 with disease annotations

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Phenotype Summary

30 phenotypes from 4 alleles in 4 genetic backgrounds
21 images
40 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

80
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

67
Radiation induced

2
Targeted

6
Genomic Mutations

3 involving Tab1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

91 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutant fetuses exhibit edema, hemorrhaging, cardiovascular and pulmonary dysmorphogenesis, and die in the late stages of gestation.

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All GO Annotations

42
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

734
Tissues

16
cDNA Data

37
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tab1

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All Sequences

47
RefSeq

4
UniProt

4
CCDS

CCDS27659.1

Ensembl

ENSMUSG00000022414 (Evidence)
NCBI Gene

66513

			Length	Strain/Species	Flank
genomic	66513	NCBI Gene Model \| MGI Sequence Detail	28576	C57BL/6J	± kb
transcript	NM_025609	RefSeq \| MGI Sequence Detail	2960	C57BL/6
polypeptide	Q8CF89	UniProt \| EBI \| MGI Sequence Detail	502	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000001770 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

(term hierarchy)
PDB

4LOO, 4LOP, 4LOQ
InterPro Domains

IPR001932 PPM-type phosphatase-like domain

IPR036457 PPM-type phosphatase-like domain superfamily

IPR015655 Protein phosphatase 2C
GlyGen

Q8CF89 3 sites, 1 O-linked glycan (3 sites)

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All nucleic 37

cDNA 37

Microarray probesets 4

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MGI:5314038

Summaries

All 84

Developmental Gene Expression 6

Diseases 1

Gene Ontology 14

Phenotypes 40
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:345487 Zhang J, et al., E3 ligase RNF99 negatively regulates TLR-mediated inflammatory immune response via K48-linked ubiquitination of TAB2. Cell Death Differ. 2023 Apr;30(4):966-978

TSS for Tab1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr132164	Chr15:80017315-80017356 (+)	3 bp
Tssr132165	Chr15:80017712-80017728 (+)	387 bp
Tssr132166	Chr15:80019438-80019442 (+)	2,107 bp
Tssr132167	Chr15:80032910-80032925 (+)	15,585 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24