Parp11 MGI Mouse Gene Detail - MGI:2141505 - poly (ADP-ribose) polymerase family, member 11

Symbol

Parp11
Name

poly (ADP-ribose) polymerase family, member 11
Synonyms

5330431N24Rik, HIN1L

Feature Type

protein coding gene
IDs

MGI:2141505
NCBI Gene: 101187
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr6:127423803-127471224 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 62.39 cM
Mapping Data

2 experiments

SNPs within 2kb

1198 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2141505	protein coding gene	Chr6:127423803-127491200 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031314	protein coding gene	Chr6:130962134-131016988 (+)
A/J	MGP_AJ_G0031285	protein coding gene	Chr6:125972937-126017912 (+)
AKR/J	MGP_AKRJ_G0031213	protein coding gene	Chr6:129371195-129418337 (+)
BALB/cJ	MGP_BALBcJ_G0031292	protein coding gene	Chr6:125530644-125578097 (+)
C3H/HeJ	MGP_C3HHeJ_G0031016	protein coding gene	Chr6:129505011-129557593 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031749	protein coding gene	Chr6:134384315-134435620 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028897	protein coding gene	Chr6:123144785-123194933 (+)
CAST/EiJ	MGP_CASTEiJ_G0030397	protein coding gene	Chr6:129719046-129775887 (+)
CBA/J	MGP_CBAJ_G0030977	protein coding gene	Chr6:139544577-139593515 (+)
DBA/2J	MGP_DBA2J_G0031133	protein coding gene	Chr6:124861740-124907422 (+)
FVB/NJ	MGP_FVBNJ_G0031082	protein coding gene	Chr6:123788270-123833202 (+)
LP/J	MGP_LPJ_G0031213	protein coding gene	Chr6:131063807-131111096 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031121	protein coding gene	Chr6:143487413-143538178 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031784	protein coding gene	Chr6:129347188-129400329 (+)
PWK/PhJ	MGP_PWKPhJ_G0030112	protein coding gene	Chr6:123142483-123189295 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029941	protein coding gene	Chr6:127433945-127487877 (+)
WSB/EiJ	MGP_WSBEiJ_G0030482	protein coding gene	Chr6:129711357-129763368 (+)

Human Ortholog

PARP11, poly(ADP-ribose) polymerase family member 11

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PARP11, poly(ADP-ribose) polymerase family member 11
Synonyms

ARTD11, C12orf6, MIB006
Links

HGNC:1186

NCBI Gene ID: 57097

neXtProt AC: NX_Q9NR21

UniProt: Q9NR21
Chr Location

12p13.32; chr12:3791047-3873448 (-) GRCh38

MGI Vertebrate Homology

Parp11 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: PARP11
Gene Tree

Parp11

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Gene trapped

10
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit impaired male fertility and teratozoospermia associated with sperm head malformations and nuclear envelope defects during the nuclear reshaping process of spermatid elongation and condensation.

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All GO Annotations

26
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

799
Tissues

23
cDNA Data

49
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase parp11

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All Sequences

81
RefSeq

32
UniProt

3
CCDS

CCDS20565.1, CCDS85162.1

Ensembl

ENSMUSG00000037997 (Evidence)
NCBI Gene

101187

			Length	Strain/Species	Flank
genomic	ENSMUSG00000037997	Ensembl Gene Model \| MGI Sequence Detail	47422	C57BL/6J	± kb
transcript	ENSMUST00000039680	Ensembl \| MGI Sequence Detail	3746	Not Applicable
polypeptide	ENSMUSP00000036127	Ensembl \| MGI Sequence Detail	331	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000012291 protein mono-ADP-ribosyltransferase PARP11

(term hierarchy)
EC

2.4.2.-
InterPro Domains

IPR051712 Mono-ADP-ribosyltransferase and antiviral protein

IPR012317 Poly(ADP-ribose) polymerase, catalytic domain

IPR004170 WWE domain

IPR037197 WWE domain superfamily

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All nucleic 49

cDNA 49

Microarray probesets 4

Summaries

All 42

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 14
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:354792 Basavaraja R, et al., PARP11 inhibition inactivates tumor-infiltrating regulatory T cells and improves the efficacy of immunotherapies. Cell Rep Med. 2024 Jul 16;5(7):101649

TSS for Parp11:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr59027	Chr6:127423755-127423766 (+)	-42 bp
Tssr59028	Chr6:127423782-127423835 (+)	6 bp
Tssr59029	Chr6:127423838-127423851 (+)	42 bp
Tssr59030	Chr6:127430571-127430625 (+)	6,795 bp
Tssr59031	Chr6:127430630-127430648 (+)	6,836 bp
Tssr59032	Chr6:127430668-127430679 (+)	6,871 bp
Tssr59033	Chr6:127432276-127432279 (+)	8,475 bp
Tssr59034	Chr6:127434319-127434334 (+)	10,524 bp
Tssr59035	Chr6:127451100-127451114 (+)	27,304 bp
Tssr2024	Chr6:127451138-127451156 (+)	27,344 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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