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Dmrta1 Gene Detail
Summary
  • Symbol
    Dmrta1
  • Name
    doublesex and mab-3 related transcription factor like family A1
  • Synonyms
    Dmrt4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2653627
    NCBI Gene: 242523
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:89576435-89583003 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 42.15 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    265 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2653627
 protein coding gene Chr4:89567673-89583009 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028443
 protein coding gene Chr4:89639392-89660562 (+)
A/J MGP_AJ_G0028405
 protein coding gene Chr4:86481874-86497183 (+)
AKR/J MGP_AKRJ_G0028353
 protein coding gene Chr4:88589069-88604420 (+)
BALB/cJ MGP_BALBcJ_G0028424
 protein coding gene Chr4:86710239-86726895 (+)
C3H/HeJ MGP_C3HHeJ_G0028136
 protein coding gene Chr4:89363556-89382777 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028863
 protein coding gene Chr4:93009117-93026209 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026158
 protein coding gene Chr4:82374826-82389933 (+)
CAST/EiJ MGP_CASTEiJ_G0027577
 protein coding gene Chr4:87198955-87219020 (+)
CBA/J MGP_CBAJ_G0028106
 protein coding gene Chr4:95916499-95933469 (+)
DBA/2J MGP_DBA2J_G0028256
 protein coding gene Chr4:86225720-86241778 (+)
FVB/NJ MGP_FVBNJ_G0028223
 protein coding gene Chr4:85170781-85187791 (+)
LP/J MGP_LPJ_G0028356
 protein coding gene Chr4:89903887-89919172 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028252
 protein coding gene Chr4:100904140-100919364 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028901
 protein coding gene Chr4:88773041-88788393 (+)
PWK/PhJ MGP_PWKPhJ_G0027301
 protein coding gene Chr4:84522681-84538512 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027122
 protein coding gene Chr4:86293010-86307980 (+)
WSB/EiJ MGP_WSBEiJ_G0027655
 protein coding gene Chr4:88961430-88977001 (+)



Homology
more
  • Human Ortholog
    DMRTA1, DMRT like family A1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DMRTA1, DMRT like family A1
  • Synonyms
    DMO, DMRT4
  • Links
    NCBI Gene ID: 63951
    neXtProt AC: NX_Q5VZB9
    UniProt: Q5VZB9

  • Chr Location
    9p21.3; chr9:22446824-22455740 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and fertile; however, females exhibit polyovular ovarian follicles while 25% of males display abnormal copulatory behavior toward other males.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    822
  • Tissues
    66
  • cDNA Data
    6
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 242523 NCBI Gene Model | MGI Sequence Detail 6569 C57BL/6J ±  kb
    transcript NM_175647 RefSeq | MGI Sequence Detail 4073 C57BL/6  
    polypeptide Q8CFG4 UniProt | EBI | MGI Sequence Detail 490 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 6
      Primer pair 6

      Microarray probesets 2
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 20
      Gene Ontology 8
      Phenotypes 10
    • Earliest
      J:68323 Carninci P, et al., Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Genome Res. 2000 Oct;10(10):1617-30
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory