Sik2 MGI Mouse Gene Detail - MGI:2445031

Symbol

Sik2
Name

salt inducible kinase 2
Synonyms

G630080D20Rik, Snf1lk2

Feature Type

protein coding gene
IDs

MGI:2445031
NCBI Gene: 235344
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr9:50804101-50920373 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 27.75 cM
Mapping Data

2 experiments

SNPs within 2kb

2020 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2445031	protein coding gene	Chr9:50800944-50920432 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0034794	protein coding gene	Chr9:49798654-49918662 (-)
A/J	MGP_AJ_G0034775	protein coding gene	Chr9:48280876-48397368 (-)
AKR/J	MGP_AKRJ_G0034703	protein coding gene	Chr9:49294018-49411643 (-)
BALB/cJ	MGP_BALBcJ_G0034767	protein coding gene	Chr9:48022489-48138439 (-)
C3H/HeJ	MGP_C3HHeJ_G0034477	protein coding gene	Chr9:49787937-49905417 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0035287	protein coding gene	Chr9:51185031-51320398 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032200	protein coding gene	Chr9:47745226-47864517 (-)
CAST/EiJ	MGP_CASTEiJ_G0033799	protein coding gene	Chr9:49731384-49845328 (-)
CBA/J	MGP_CBAJ_G0034449	protein coding gene	Chr9:53010403-53130984 (-)
DBA/2J	MGP_DBA2J_G0034608	protein coding gene	Chr9:48144876-48263492 (-)
FVB/NJ	MGP_FVBNJ_G0034549	protein coding gene	Chr9:47360856-47476333 (-)
LP/J	MGP_LPJ_G0034689	protein coding gene	Chr9:50162791-50286028 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034592	protein coding gene	Chr9:54594018-54717502 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035308	protein coding gene	Chr9:49281052-49401694 (-)
PWK/PhJ	MGP_PWKPhJ_G0033504	protein coding gene	Chr9:48118993-48236703 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0033339	protein coding gene	Chr9:49582123-49704196 (-)
WSB/EiJ	MGP_WSBEiJ_G0033912	protein coding gene	Chr9:49280295-49402002 (-)

Human Ortholog

SIK2, salt inducible kinase 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SIK2, salt inducible kinase 2
Synonyms

LOH11CR1I, QIK, SIK-2, SNF1LK2
Links

HGNC:21680

NCBI Gene ID: 23235

neXtProt AC: NX_Q9H0K1

UniProt: Q9H0K1
Chr Location

11q23.1; chr11:111602449-111730855 (+) GRCh38

MGI Vertebrate Homology

Sik2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SIK2
Protein SuperFamily

Ser/Thr_PK_SNF1-like
Gene Tree

Sik2

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Phenotype Summary

19 phenotypes from 3 alleles in 3 genetic backgrounds
1 phenotype from multigenic genotypes
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

28
Endonuclease-mediated

6
Gene trapped

14
Targeted

8
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

45 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice heterozygous for a knock-out allele exhibit darkened hair color in an agouti background.

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All GO Annotations

31
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

710
Tissues

3
cDNA Data

11
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sik2

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All Sequences

58
RefSeq

9
UniProt

6
CCDS

CCDS40627.1

Ensembl

ENSMUSG00000037112 (Evidence)
NCBI Gene

235344

			Length	Strain/Species	Flank
genomic	ENSMUSG00000037112	Ensembl Gene Model \| MGI Sequence Detail	116273	C57BL/6J	± kb
transcript	ENSMUST00000041375	Ensembl \| MGI Sequence Detail	3552	Not Applicable
polypeptide	ENSMUSP00000038761	Ensembl \| MGI Sequence Detail	931	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000014871 serine/threonine-protein kinase SIK2

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR034672 Salt-Inducible kinase, catalytic domain

IPR008271 Serine/threonine-protein kinase, active site

IPR017090 Serine/threonine-protein kinase, SIK1/2

IPR015940 Ubiquitin-associated domain
GlyGen

Q8CFH6 1 site, 1 O-linked glycan (1 site)

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All nucleic 12

cDNA 11

Primer pair 1

Microarray probesets 3

Summaries

All 61

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 26
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Sik2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr89522	Chr9:50920266-50920380 (-)	50 bp
Tssr89521	Chr9:50884039-50884043 (-)	36,332 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24