Polr2b MGI Mouse Gene Detail - MGI:2388280 - polymerase (RNA) II (DNA directed) polypeptide B

Symbol

Polr2b
Name

polymerase (RNA) II (DNA directed) polypeptide B
Synonyms

MGC:47046, RPB2

Feature Type

protein coding gene
IDs

MGI:2388280
NCBI Gene: 231329
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr5:77458331-77497175 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 41.66 cM
Mapping Data

1 experiment

SNPs within 2kb

955 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2388280	protein coding gene	Chr5:77457994-77497175 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029658	protein coding gene	Chr5:77583056-77627442 (+)
A/J	MGP_AJ_G0029626	protein coding gene	Chr5:74581576-74621435 (+)
AKR/J	MGP_AKRJ_G0029574	protein coding gene	Chr5:77038385-77081115 (+)
BALB/cJ	MGP_BALBcJ_G0029635	protein coding gene	Chr5:75322483-75362182 (+)
C3H/HeJ	MGP_C3HHeJ_G0029358	protein coding gene	Chr5:77394104-77436047 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030089	protein coding gene	Chr5:80659038-80711479 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027329	protein coding gene	Chr5:70316063-70355463 (+)
CAST/EiJ	MGP_CASTEiJ_G0028766	protein coding gene	Chr5:76617621-76659631 (+)
CBA/J	MGP_CBAJ_G0029327	protein coding gene	Chr5:83342750-83385498 (+)
DBA/2J	MGP_DBA2J_G0029472	protein coding gene	Chr5:74640577-74680538 (+)
FVB/NJ	MGP_FVBNJ_G0029433	protein coding gene	Chr5:73850695-73889840 (+)
LP/J	MGP_LPJ_G0029559	protein coding gene	Chr5:77985898-78025890 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029461	protein coding gene	Chr5:86437168-86483393 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030122	protein coding gene	Chr5:76583198-76626960 (+)
PWK/PhJ	MGP_PWKPhJ_G0028489	protein coding gene	Chr5:73663474-73704427 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028324	protein coding gene	Chr5:75957664-75998295 (+)
WSB/EiJ	MGP_WSBEiJ_G0028846	protein coding gene	Chr5:76905703-76947632 (+)

Human Ortholog

POLR2B, RNA polymerase II subunit B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

POLR2B, RNA polymerase II subunit B
Synonyms

hRPB140, POL2RB, RPB2
Links

HGNC:9188

NCBI Gene ID: 5431

neXtProt AC: NX_P30876

UniProt: P30876
Chr Location

4q12; chr4:56977722-57031158 (+) GRCh38

MGI Vertebrate Homology

Polr2b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: POLR2B
Gene Tree

Polr2b

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Phenotype Summary

6 phenotypes from 1 allele in 2 genetic backgrounds
1 images
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

24
Chemically induced (other)

2
Endonuclease-mediated

3
Gene trapped

16
Spontaneous

1
Targeted

2
Genomic Mutations

3 involving Polr2b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

62 strains or lines available

Mice homozygous for a knock-out allele show abnormal morula morphology and complete embryonic lethality before implantation. In vitro, embryos fail to hatch from the zona pellucida and die after 3 days in culture.

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All GO Annotations

34
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

956
Tissues

120
cDNA Data

10
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase polr2b

ZFIN polr2b

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All Sequences

37
RefSeq

2
UniProt

1
CCDS

CCDS51528.1

Ensembl

ENSMUSG00000029250 (Evidence)
NCBI Gene

231329

			Length	Strain/Species	Flank
genomic	231329	NCBI Gene Model \| MGI Sequence Detail	38845	C57BL/6J	± kb
transcript	NM_153798	RefSeq \| MGI Sequence Detail	3812	C57BL/6
polypeptide	Q8CFI7	UniProt \| EBI \| MGI Sequence Detail	1174	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000012988 DNA-directed RNA polymerase II subunit RPB2

(term hierarchy)
EC

2.7.7.48, 2.7.7.6, 3.1.13.-
InterPro Domains

IPR015712 DNA-directed RNA polymerase, subunit 2

IPR007120 DNA-directed RNA polymerase, subunit 2, hybrid-binding domain

IPR037033 DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily

IPR007121 RNA polymerase, beta subunit, conserved site

IPR007644 RNA polymerase, beta subunit, protrusion

IPR007642 RNA polymerase Rpb2, domain 2

IPR037034 RNA polymerase Rpb2, domain 2 superfamily

IPR007645 RNA polymerase Rpb2, domain 3

IPR007646 RNA polymerase Rpb2, domain 4

IPR007647 RNA polymerase Rpb2, domain 5

IPR007641 RNA polymerase Rpb2, domain 7

IPR014724 RNA polymerase Rpb2, OB-fold
GlyGen

Q8CFI7 1 site, 1 O-linked glycan (1 site)

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All nucleic 11

cDNA 10

Primer pair 1

Microarray probesets 2

Summaries

All 48

Developmental Gene Expression 4

Gene Ontology 9

Phenotypes 17
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:346124 Feng Z, et al., TANGO6 regulates cell proliferation via COPI vesicle-mediated RPB2 nuclear entry. Nat Commun. 2024 Mar 15;15(1):2371

TSS for Polr2b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr46788	Chr5:77458325-77458392 (+)	28 bp
Tssr46789	Chr5:77460390-77460407 (+)	2,068 bp
Tssr46790	Chr5:77497085-77497123 (+)	38,773 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24