Trp53inp2 MGI Mouse Gene Detail - MGI:1915978 - transformation related protein 53 inducible nuclear protein 2

Symbol

Trp53inp2
Name

transformation related protein 53 inducible nuclear protein 2
Synonyms

1110029F20Rik, Tp53inp2

Feature Type

protein coding gene
IDs

MGI:1915978
NCBI Gene: 68728
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr2:155223742-155231767 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 77.26 cM
Mapping Data

1 experiment

SNPs within 2kb

183 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915978	protein coding gene	Chr2:155222979-155231770 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026733	protein coding gene	Chr2:160197510-160206253 (+)
A/J	MGP_AJ_G0026699	protein coding gene	Chr2:153830138-153838961 (+)
AKR/J	MGP_AKRJ_G0026670	protein coding gene	Chr2:158294268-158303058 (+)
BALB/cJ	MGP_BALBcJ_G0026708	protein coding gene	Chr2:154131583-154140644 (+)
C3H/HeJ	MGP_C3HHeJ_G0026451	protein coding gene	Chr2:158650722-158660892 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027157	protein coding gene	Chr2:164890197-164900576 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024527	protein coding gene	Chr2:147333025-147341686 (+)
CAST/EiJ	MGP_CASTEiJ_G0025912	protein coding gene	Chr2:158958654-158969595 (+)
CBA/J	MGP_CBAJ_G0026428	protein coding gene	Chr2:170889579-170899242 (+)
DBA/2J	MGP_DBA2J_G0026565	protein coding gene	Chr2:153012711-153021882 (+)
FVB/NJ	MGP_FVBNJ_G0026532	protein coding gene	Chr2:151392570-151402783 (+)
LP/J	MGP_LPJ_G0026670	protein coding gene	Chr2:160339514-160348274 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026553	protein coding gene	Chr2:174892904-174901613 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027213	protein coding gene	Chr2:158182873-158191595 (+)
PWK/PhJ	MGP_PWKPhJ_G0025646	protein coding gene	Chr2:152514079-152523250 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025449	protein coding gene	Chr2:157106867-157116106 (+)
WSB/EiJ	MGP_WSBEiJ_G0025982	protein coding gene	Chr2:159066858-159078673 (+)

Human Ortholog

TP53INP2, tumor protein p53 inducible nuclear protein 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TP53INP2, tumor protein p53 inducible nuclear protein 2
Synonyms

C20orf110, dJ1181N3.1, DOR, PIG-U, PIGU, PINH
Links

HGNC:16104

NCBI Gene ID: 58476

neXtProt AC: NX_Q8IXH6

UniProt: Q8IXH6
Chr Location

20q11.22; chr20:34704339-34713439 (+) GRCh38

MGI Vertebrate Homology

Trp53inp2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TP53INP2
Gene Tree

Trp53inp2

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Phenotype Summary

27 phenotypes from 3 alleles in 3 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

4
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

10 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

22
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

835
Tissues

88
cDNA Data

13
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

106
RefSeq

20
UniProt

6
CCDS

CCDS16947.1

Ensembl

ENSMUSG00000038375 (Evidence)
NCBI Gene

68728

			Length	Strain/Species	Flank
genomic	68728	NCBI Gene Model \| MGI Sequence Detail	8026	C57BL/6J	± kb
transcript	NM_001418655	RefSeq \| MGI Sequence Detail	4493	C57BL/6
polypeptide	Q8CFU8	UniProt \| EBI \| MGI Sequence Detail	221	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000016562 tumor protein p53-inducible nuclear protein 2

(term hierarchy)
InterPro Domains

IPR029431 Tumour protein p53-inducible nuclear protein

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All nucleic 16

Genomic 1

cDNA 13

Primer pair 1

Other 1

Microarray probesets 3

Summaries

All 36

Developmental Gene Expression 5

Gene Ontology 7

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Trp53inp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr21086	Chr2:155223728-155223804 (+)	24 bp
Tssr21087	Chr2:155224106-155224194 (+)	408 bp
Tssr21088	Chr2:155224204-155224219 (+)	470 bp
Tssr21089	Chr2:155224953-155224964 (+)	1,217 bp
Tssr21090	Chr2:155224968-155224986 (+)	1,235 bp
Tssr21091	Chr2:155224991-155225000 (+)	1,254 bp
Tssr21092	Chr2:155226484-155226488 (+)	2,744 bp
Tssr21093	Chr2:155227810-155227836 (+)	4,081 bp
Tssr21094	Chr2:155227845-155227869 (+)	4,115 bp
Tssr21095	Chr2:155228030-155228054 (+)	4,300 bp
Tssr21096	Chr2:155228724-155228744 (+)	4,992 bp
Tssr21097	Chr2:155228790-155228816 (+)	5,061 bp
Tssr21098	Chr2:155228855-155228872 (+)	5,122 bp
Tssr21099	Chr2:155228918-155228931 (+)	5,183 bp
Tssr21100	Chr2:155228947-155228975 (+)	5,219 bp
Tssr21101	Chr2:155231013-155231018 (+)	7,274 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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