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Shf Gene Detail
Summary
  • Symbol
    Shf
  • Name
    Src homology 2 domain containing F
  • Feature Type
    protein coding gene
  • IDs
    MGI:3613669
    NCBI Gene: 435684
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:122179373-122199643 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 60.63 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    541 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3613669
 protein coding gene Chr2:122179373-122199650 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026414
 protein coding gene Chr2:125349415-125371058 (-)
A/J MGP_AJ_G0026376
 protein coding gene Chr2:120224148-120244562 (-)
AKR/J MGP_AKRJ_G0026353
 protein coding gene Chr2:123593532-123615450 (-)
BALB/cJ MGP_BALBcJ_G0026388
 protein coding gene Chr2:120455032-120475415 (-)
C3H/HeJ MGP_C3HHeJ_G0026133
 protein coding gene Chr2:124075824-124096282 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026835
 protein coding gene Chr2:129418516-129438798 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024214
 protein coding gene Chr2:115194770-115215412 (-)
CAST/EiJ MGP_CASTEiJ_G0025595
 protein coding gene Chr2:124416649-124436932 (-)
CBA/J MGP_CBAJ_G0026112
 protein coding gene Chr2:133975375-133998872 (-)
DBA/2J MGP_DBA2J_G0026248
 protein coding gene Chr2:119621525-119641913 (-)
FVB/NJ MGP_FVBNJ_G0026211
 protein coding gene Chr2:118413871-118435318 (-)
LP/J MGP_LPJ_G0026351
 protein coding gene Chr2:125596243-125616536 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026231
 protein coding gene Chr2:138179391-138202229 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026890
 protein coding gene Chr2:123709109-123729503 (-)
PWK/PhJ MGP_PWKPhJ_G0025331
 protein coding gene Chr2:119236023-119261055 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025131
 protein coding gene Chr2:122851725-122872254 (-)
WSB/EiJ MGP_WSBEiJ_G0025667
 protein coding gene Chr2:124570196-124591803 (-)



Homology
more
  • Human Ortholog
    SHF, Src homology 2 domain containing F
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SHF, Src homology 2 domain containing F
  • Links
    NCBI Gene ID: 90525
    UniProt: Q7M4L6

  • Chr Location
    15q21.1; chr15:45167214-45201175 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    1
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    897
  • Tissues
    30
  • cDNA Data
    42
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033256 Ensembl Gene Model | MGI Sequence Detail 20271 C57BL/6J ±  kb
transcript ENSMUST00000125826 Ensembl | MGI Sequence Detail 1566 Not Applicable  
polypeptide ENSMUSP00000117099 Ensembl | MGI Sequence Detail 446 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 42
    cDNA 42

    Microarray probesets 2
References
more
  • Summaries
    All 29
    Developmental Gene Expression 2
    Gene Ontology 1
    Phenotypes 10
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory