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Dym Gene Detail
Summary
  • Symbol
    Dym
  • Name
    dymeclin
  • Synonyms
    1810041M12Rik, 4933427L07Rik, C030019K18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918480
    NCBI Gene: 69190
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:75151852-75420035 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 50.97 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    8190 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918480
 protein coding gene Chr18:75151772-75420037 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024563
 protein coding gene Chr18:75695489-75976523 (+)
A/J MGP_AJ_G0024530
 protein coding gene Chr18:72382210-72655144 (+)
AKR/J MGP_AKRJ_G0024501
 protein coding gene Chr18:74548444-74827462 (+)
BALB/cJ MGP_BALBcJ_G0024530
 protein coding gene Chr18:72581429-72856157 (+)
C3H/HeJ MGP_C3HHeJ_G0024298
 protein coding gene Chr18:74636417-74916006 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024976
 protein coding gene Chr18:77675716-77964911 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022406
 protein coding gene Chr18:71442903-71716982 (+)
CAST/EiJ MGP_CASTEiJ_G0023771
 protein coding gene Chr18:74817005-75116218 (+)
CBA/J MGP_CBAJ_G0024267
 protein coding gene Chr18:80336858-80658218 (+)
DBA/2J MGP_DBA2J_G0024397
 protein coding gene Chr18:71977674-72245724 (+)
FVB/NJ MGP_FVBNJ_G0024363
 protein coding gene Chr18:71317898-71593433 (+)
LP/J MGP_LPJ_G0024481
 protein coding gene Chr18:75553161-75839329 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024393
 protein coding gene Chr18:81766022-82071766 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025024
 protein coding gene Chr18:74677872-74954330 (+)
PWK/PhJ MGP_PWKPhJ_G0023515
 protein coding gene Chr18:72355699-72633291 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023319
 protein coding gene Chr18:74809494-75102015 (+)
WSB/EiJ MGP_WSBEiJ_G0023834
 protein coding gene Chr18:74613647-74895264 (+)



Homology
more
  • Human Ortholog
    DYM, dymeclin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DYM, dymeclin
  • Synonyms
    DMC, SMC
  • Links
    NCBI Gene ID: 54808
    neXtProt AC: NX_Q7RTS9
    UniProt: Q7RTS9

  • Chr Location
    18q21.1; chr18:49036387-49461347 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Dym mouse models; 3 with human DYM associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    41 phenotypes from 2 alleles in 2 genetic backgrounds
    5 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele display decreased body size with short tubular bones, chondrodysplasia, partial penetrance of obstructive hydronephrosis and impaired vesicular transport.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    4
  • cDNA Data
    85
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035765 Ensembl Gene Model | MGI Sequence Detail 268184 C57BL/6J ±  kb
    transcript ENSMUST00000039608 Ensembl | MGI Sequence Detail 2456 Not Applicable  
    polypeptide ENSMUSP00000047054 Ensembl | MGI Sequence Detail 669 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 90
      cDNA 90

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1916440, MGI:1924708
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 4
      Phenotypes 16
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory