Slain2 MGI Mouse Gene Detail - MGI:1923241 - SLAIN motif family, member 2

Symbol

Slain2
Name

SLAIN motif family, member 2
Synonyms

5033405K12Rik, 8030444K12Rik, mKIAA1458

Feature Type

protein coding gene
IDs

MGI:1923241
NCBI Gene: 75991
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr5:73071705-73136184 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 38.44 cM
Mapping Data

2 experiments

SNPs within 2kb

1476 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923241	protein coding gene	Chr5:73071647-73136184 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029618	protein coding gene	Chr5:72878013-72946434 (+)
A/J	MGP_AJ_G0029586	protein coding gene	Chr5:70154223-70216172 (+)
AKR/J	MGP_AKRJ_G0029534	protein coding gene	Chr5:72398365-72468358 (+)
BALB/cJ	MGP_BALBcJ_G0029594	protein coding gene	Chr5:70860786-70931601 (+)
C3H/HeJ	MGP_C3HHeJ_G0029319	protein coding gene	Chr5:72786752-72851578 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030049	protein coding gene	Chr5:75865331-75933893 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027291	protein coding gene	Chr5:65858763-65921615 (+)
CAST/EiJ	MGP_CASTEiJ_G0028728	protein coding gene	Chr5:71883489-71954214 (+)
CBA/J	MGP_CBAJ_G0029287	protein coding gene	Chr5:78323797-78398298 (+)
DBA/2J	MGP_DBA2J_G0029434	protein coding gene	Chr5:70206114-70271916 (+)
FVB/NJ	MGP_FVBNJ_G0029394	protein coding gene	Chr5:69369209-69439247 (+)
LP/J	MGP_LPJ_G0029518	protein coding gene	Chr5:73326452-73392233 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029420	protein coding gene	Chr5:81649561-81720608 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030083	protein coding gene	Chr5:71974320-72039696 (+)
PWK/PhJ	MGP_PWKPhJ_G0028450	protein coding gene	Chr5:69185893-69250841 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028283	protein coding gene	Chr5:71300817-71367876 (+)
WSB/EiJ	MGP_WSBEiJ_G0028808	protein coding gene	Chr5:72264865-72329431 (+)

Human Ortholog

SLAIN2, SLAIN motif family member 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLAIN2, SLAIN motif family member 2
Synonyms

KIAA1458
Links

HGNC:29282

NCBI Gene ID: 57606

neXtProt AC: NX_Q9P270

UniProt: Q9P270
Chr Location

4p11; chr4:48341529-48426201 (+) GRCh38

MGI Vertebrate Homology

Slain2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLAIN2
Gene Tree

Slain2

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References

1 with disease annotations

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
369 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

23
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

15
Radiation induced

1
Spontaneous

3
Targeted

1
Genomic Mutations

6 involving Slain2
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

21
GO References

5

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

750
Tissues

17
cDNA Data

90
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slain2l

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All Sequences

64
RefSeq

6
UniProt

3
CCDS

CCDS19335.2, CCDS51517.1

Ensembl

ENSMUSG00000036087 (Evidence)
NCBI Gene

75991

			Length	Strain/Species	Flank
genomic	75991	NCBI Gene Model \| MGI Sequence Detail	64480	C57BL/6J	± kb
transcript	NM_153567	RefSeq \| MGI Sequence Detail	4865	C57BL/6
polypeptide	Q8CI08	UniProt \| EBI \| MGI Sequence Detail	581	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000030485 SLAIN motif-containing protein 2

(term hierarchy)
InterPro Domains

IPR026179 SLAIN motif-containing protein
GlyGen

Q8CI08 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

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All nucleic 92

cDNA 91

Primer pair 1

Microarray probesets 7

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MGI:2140939, MGI:2444168

Summaries

All 401

Developmental Gene Expression 4

Diseases 1

Gene Ontology 5

Phenotypes 369
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:360413 Ji Z, et al., Mrgprb2-mediated mast cell activation exacerbates Modic changes by regulating immune niches. Exp Mol Med. 2024 May;56(5):1178-1192

TSS for Slain2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr46623	Chr5:73071607-73071646 (+)	-78 bp
Tssr46624	Chr5:73071650-73071692 (+)	-34 bp
Tssr46625	Chr5:73071695-73071726 (+)	6 bp
Tssr46626	Chr5:73071754-73071819 (+)	82 bp
Tssr46627	Chr5:73071850-73071863 (+)	152 bp
Tssr46628	Chr5:73071897-73071908 (+)	198 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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