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Pak2 Gene Detail
Summary
  • Symbol
    Pak2
  • Name
    p21 (RAC1) activated kinase 2
  • Synonyms
    5330420P17Rik, A130002K10Rik, D16Ertd269e, PAK-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339984
    NCBI Gene: 224105
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:31835108-31898160 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 22.40 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1342 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1339984
 protein coding gene Chr16:31835108-31898160 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022727
 protein coding gene Chr16:30033904-30105041 (-)
A/J MGP_AJ_G0022692
 protein coding gene Chr16:28646396-28709723 (-)
AKR/J MGP_AKRJ_G0022665
 protein coding gene Chr16:29688221-29752500 (-)
BALB/cJ MGP_BALBcJ_G0022694
 protein coding gene Chr16:28797672-28860870 (-)
C3H/HeJ MGP_C3HHeJ_G0022459
 protein coding gene Chr16:29808964-29875751 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023143
 protein coding gene Chr16:30685678-30755021 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020661
 protein coding gene Chr16:29014882-29080968 (-)
CAST/EiJ MGP_CASTEiJ_G0021987
 protein coding gene Chr16:29941762-30005912 (-)
CBA/J MGP_CBAJ_G0022429
 protein coding gene Chr16:31938260-32013305 (-)
DBA/2J MGP_DBA2J_G0022562
 protein coding gene Chr16:28496837-28561726 (-)
FVB/NJ MGP_FVBNJ_G0022537
 protein coding gene Chr16:28481507-28545471 (-)
LP/J MGP_LPJ_G0022629
 protein coding gene Chr16:29815853-29889000 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022556
 protein coding gene Chr16:31401231-31466739 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023155
 protein coding gene Chr16:29665729-29729836 (-)
PWK/PhJ MGP_PWKPhJ_G0021726
 protein coding gene Chr16:28814980-28853625 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021557
 protein coding gene Chr16:29443648-29516290 (-)
WSB/EiJ MGP_WSBEiJ_G0022031
 protein coding gene Chr16:29602759-29669486 (-)



Homology
more
  • Human Ortholog
    PAK2, p21 (RAC1) activated kinase 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PAK2, p21 (RAC1) activated kinase 2
  • Synonyms
    KNO2, PAK65, PAKgamma
  • Links
    NCBI Gene ID: 5062
    neXtProt AC: NX_Q13177
    UniProt: Q13177

  • Chr Location
    3q29; chr3:196739857-196832647 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Pak2 mouse models; 1 with human PAK2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 6 alleles in 5 genetic backgrounds
    1 images
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit lethality between E8 and the postnatal period with prominent head folds, impaired somite development, and growth retardation. Mice homozygous for a knock-in allele exhibit increased cell proliferation and decreased apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    84
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    788
  • Tissues
    30
  • cDNA Data
    15
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 224105 NCBI Gene Model | MGI Sequence Detail 63053 C57BL/6J ±  kb
    transcript NM_177326 RefSeq | MGI Sequence Detail 5741 ZRU/MplStud  
    polypeptide Q8CIN4 UniProt | EBI | MGI Sequence Detail 524 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 15
      Primer pair 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1098647, MGI:1924351, MGI:2146488, MGI:2442429
    References
    more
    • Summaries
      All 107
      Developmental Gene Expression 18
      Diseases 1
      Gene Ontology 16
      Phenotypes 39
    • Earliest
      J:46940 Zambrowicz BP, et al., Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells. Nature. 1998 Apr 9;392(6676):608-11
    • Latest
      J:357470 Hu B, et al., PAK2 is necessary for myelination in the peripheral nervous system. Brain. 2024 May 3;147(5):1809-1821
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory