Dock3 MGI Mouse Gene Detail - MGI:2429763 - dedicator of cyto-kinesis 3

Symbol

Dock3
Name

dedicator of cyto-kinesis 3
Synonyms

Moca, PBP

Feature Type

protein coding gene
IDs

MGI:2429763
NCBI Gene: 208869
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr9:106770024-107109108 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 57.98 cM
Mapping Data

1 experiment

SNPs within 2kb

5769 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2429763	protein coding gene	Chr9:106770024-107109108 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0035247	protein coding gene	Chr9:108743079-109086995 (-)
A/J	MGP_AJ_G0035226	protein coding gene	Chr9:104794130-105124698 (-)
AKR/J	MGP_AKRJ_G0035158	protein coding gene	Chr9:107396476-107742561 (-)
BALB/cJ	MGP_BALBcJ_G0035220	protein coding gene	Chr9:104474582-104795101 (-)
C3H/HeJ	MGP_C3HHeJ_G0034930	protein coding gene	Chr9:107813651-108144710 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0035740	protein coding gene	Chr9:111723752-112083342 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032638	protein coding gene	Chr9:102269973-102556491 (-)
CAST/EiJ	MGP_CASTEiJ_G0034241	protein coding gene	Chr9:107740848-108072679 (-)
CBA/J	MGP_CBAJ_G0034898	protein coding gene	Chr9:115701111-116060545 (-)
DBA/2J	MGP_DBA2J_G0035059	protein coding gene	Chr9:104248998-104579246 (-)
FVB/NJ	MGP_FVBNJ_G0035007	protein coding gene	Chr9:103032363-103337761 (-)
LP/J	MGP_LPJ_G0035135	protein coding gene	Chr9:108948485-109293623 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035046	protein coding gene	Chr9:117255670-117646270 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035761	protein coding gene	Chr9:107676138-108010939 (-)
PWK/PhJ	MGP_PWKPhJ_G0033948	protein coding gene	Chr9:104564782-104891524 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0033783	protein coding gene	Chr9:107746072-108071341 (-)
WSB/EiJ	MGP_WSBEiJ_G0034362	protein coding gene	Chr9:107574329-107897672 (-)

Human Ortholog

DOCK3, dedicator of cytokinesis 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DOCK3, dedicator of cytokinesis 3
Synonyms

MOCA, NEDIDHA, PBP
Links

HGNC:2989

NCBI Gene ID: 1795

neXtProt AC: NX_Q8IZD9

UniProt: Q8IZD9
Chr Location

3p21.2; chr3:50674927-51384198 (+) GRCh38

MGI Vertebrate Homology

Dock3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DOCK3
Gene Tree

Dock3

Diseases

1 with human DOCK3 associations

				Human Disease	Mouse Models
				attention deficit hyperactivity disorder IDs attention deficit hyperactivity disorder DOID:1094 DOID:1093 EFO:0003888 ICD9CM:314.8 MESH:D001289 OMIM:143465 OMIM:608903 OMIM:608904 OMIM:608905 OMIM:608906 OMIM:612311 OMIM:612312 UMLS_CUI:C0041671

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

19 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

4
Gene trapped

1
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

97 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit abnormal behaviors and muscular weakness associated with axonal dystrophy.

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All GO Annotations

12
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

746
Tissues

27
cDNA Data

41
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dock3

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All Sequences

80
RefSeq

24
UniProt

8
CCDS

CCDS40760.1

Ensembl

ENSMUSG00000039716 (Evidence)
NCBI Gene

208869

			Length	Strain/Species	Flank
genomic	208869	NCBI Gene Model \| MGI Sequence Detail	339085	C57BL/6J	± kb
transcript	NM_153413	RefSeq \| MGI Sequence Detail	9067	C57BL/6
polypeptide	Q8CIQ7	UniProt \| EBI \| MGI Sequence Detail	2027	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000006620 dedicator of cytokinesis protein 3

(term hierarchy)
InterPro Domains

IPR016024 Armadillo-type fold

IPR027007 C2 DOCK-type domain

IPR035892 C2 domain superfamily

IPR026791 Dedicator of cytokinesis

IPR035767 Dedicator of cytokinesis 3, SH3 domain

IPR037811 Dedicator of cytokinesis B, C2 domain

IPR043161 Dedicator of cytokinesis, C-terminal, lobe A

IPR043162 Dedicator of cytokinesis, C-terminal, lobe C

IPR032376 Dedicator of cytokinesis, N-terminal domain

IPR042455 Dedicator of cytokinesis, N-terminal, subdomain 1

IPR026800 Dedicator of cytokinesis protein 3, DHR2 domain

IPR027357 DOCKER domain

IPR046769 DOCKER, Lobe A

IPR046770 DOCKER, Lobe B

IPR046773 DOCKER, Lobe C

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily
GlyGen

Q8CIQ7 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

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All nucleic 44

Genomic 2

cDNA 41

Other 1

Microarray probesets 4

Summaries

All 42

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 9
Earliest

J:79164 Kashiwa A, et al., Isolation and characterization of novel presenilin binding protein. J Neurochem. 2000 Jul;75(1):109-16
Latest

J:341576 Samani A, et al., DOCK3 regulates normal skeletal muscle regeneration and glucose metabolism. FASEB J. 2023 Oct;37(10):e23198

TSS for Dock3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr91362	Chr9:107109108-107109117 (-)	-5 bp
Tssr91361	Chr9:107109015-107109093 (-)	54 bp
Tssr91360	Chr9:106857157-106857160 (-)	251,949 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24