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Crh Gene Detail
Summary
  • Symbol
    Crh
  • Name
    corticotropin releasing hormone
  • Synonyms
    corticotropin releasing factor, corticotropin-releasing factor, CRF, LOC383938
  • Feature Type
    protein coding gene
  • IDs
    MGI:88496
    NCBI Gene: 12918
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:19747565-19749560 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 5.75 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    144 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88496
 protein coding gene Chr3:19747565-19749560 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027096
 protein coding gene Chr3:16895151-16897146 (-)
A/J MGP_AJ_G0027056
 protein coding gene Chr3:16820792-16822787 (-)
AKR/J MGP_AKRJ_G0027025
 protein coding gene Chr3:16985507-16987502 (-)
BALB/cJ MGP_BALBcJ_G0027068
 protein coding gene Chr3:16576290-16578285 (-)
C3H/HeJ MGP_C3HHeJ_G0026809
 protein coding gene Chr3:17005948-17007943 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027513
 protein coding gene Chr3:17981303-17983298 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024875
 protein coding gene Chr3:14898042-14900041 (-)
CAST/EiJ MGP_CASTEiJ_G0026264
 protein coding gene Chr3:16917570-16919565 (-)
CBA/J MGP_CBAJ_G0026787
 protein coding gene Chr3:18356340-18358335 (-)
DBA/2J MGP_DBA2J_G0026921
 protein coding gene Chr3:16428261-16430256 (-)
FVB/NJ MGP_FVBNJ_G0026889
 protein coding gene Chr3:16084611-16086606 (-)
LP/J MGP_LPJ_G0027033
 protein coding gene Chr3:17547194-17549189 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026910
 protein coding gene Chr3:20435662-20437657 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027572
 protein coding gene Chr3:16732891-16734886 (-)
PWK/PhJ MGP_PWKPhJ_G0025997
 protein coding gene Chr3:16141305-16143300 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025805
 protein coding gene Chr3:16588651-16590648 (-)
WSB/EiJ MGP_WSBEiJ_G0026337
 protein coding gene Chr3:16785611-16787606 (-)



Homology
more
  • Human Ortholog
    CRH, corticotropin releasing hormone
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CRH, corticotropin releasing hormone
  • Synonyms
    CRF, CRH1
  • Links
    NCBI Gene ID: 1392
    neXtProt AC: NX_P06850
    UniProt: P06850

  • Chr Location
    8q13.1; chr8:66176376-66178464 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Crh mouse models; 2 with human CRH associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    90 phenotypes from 6 alleles in 7 genetic backgrounds
    3 phenotypes from multigenic genotypes
    215 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice have abnormal adrenal gland morphology, decreased corticosterone levels and abnormal corticosteroid responses to stress. Homozygous litters born from homozygous females display neonatal lethality, impaired lung maturation and delayedcornified and granular layer development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    97
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    975
  • Tissues
    78
  • cDNA Data
    8
  • Literature Summary
    44
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12918 NCBI Gene Model | MGI Sequence Detail 1996 C57BL/6J ±  kb
    transcript NM_205769 RefSeq | MGI Sequence Detail 1338 ZRU/MplStud  
    polypeptide Q8CIT0 UniProt | EBI | MGI Sequence Detail 187 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      Genomic 2
      cDNA 8
      Primer pair 3
      Other 5

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-2138, MGI:2686193
    References
    more
    • Summaries
      All 329
      Developmental Gene Expression 44
      Diseases 2
      Gene Ontology 10
      Phenotypes 215
    • Earliest
      J:19717 Vale W, et al., Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. Science. 1981 Sep 18;213(4514):1394-7
    • Latest
      J:352930 Lv SS, et al., Corticotropin-releasing hormone neurons control trigeminal neuralgia-induced anxiodepression via a hippocampus-to-prefrontal circuit. Sci Adv. 2024 Jan 19;10(3):eadj4196
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory