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Ovol2 Gene Detail
Summary
  • Symbol
    Ovol2
  • Name
    ovo like zinc finger 2
  • Synonyms
    1810007D21Rik, M-OVO, movo2, M-OVO-A, M-OVO-B, Ovol2, Zfp339
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338039
    NCBI Gene: 107586
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:144147095-144174000 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 70.99 cM, cytoband H1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    748 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338039
 protein coding gene Chr2:144147095-144174066 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026583
 protein coding gene Chr2:148385933-148415912 (-)
A/J MGP_AJ_G0026547
 protein coding gene Chr2:142379505-142406945 (-)
AKR/J MGP_AKRJ_G0026521
 protein coding gene Chr2:146471070-146497955 (-)
BALB/cJ MGP_BALBcJ_G0026559
 protein coding gene Chr2:142827077-142854053 (-)
C3H/HeJ MGP_C3HHeJ_G0026302
 protein coding gene Chr2:147009657-147041098 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027004
 protein coding gene Chr2:152846324-152873381 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024381
 protein coding gene Chr2:136561329-136588396 (-)
CAST/EiJ MGP_CASTEiJ_G0025763
 protein coding gene Chr2:147348415-147375471 (-)
CBA/J MGP_CBAJ_G0026282
 protein coding gene Chr2:158415373-158445948 (-)
DBA/2J MGP_DBA2J_G0026416
 protein coding gene Chr2:141667487-141694466 (-)
FVB/NJ MGP_FVBNJ_G0026380
 protein coding gene Chr2:140253773-140280442 (-)
LP/J MGP_LPJ_G0026520
 protein coding gene Chr2:148544473-148571468 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026400
 protein coding gene Chr2:162610690-162638575 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027059
 protein coding gene Chr2:146463552-146494825 (-)
PWK/PhJ MGP_PWKPhJ_G0025499
 protein coding gene Chr2:141323366-141351138 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025300
 protein coding gene Chr2:145508954-145539348 (-)
WSB/EiJ MGP_WSBEiJ_G0025836
 protein coding gene Chr2:147483982-147511452 (-)



Homology
more
  • Human Ortholog
    OVOL2, ovo like zinc finger 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OVOL2, ovo like zinc finger 2
  • Synonyms
    CHED, CHED1, CHED2, EUROIMAGE566589, PPCD1, ZNF339
  • Links
    NCBI Gene ID: 58495
    neXtProt AC: NX_Q9BRP0
    UniProt: Q9BRP0

  • Chr Location
    20p11.23; chr20:17956979-18059188 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human OVOL2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    49 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a null allele are small and die at E9.5-E10.5 with an open neural tube, impaired extraembryonic and embryonic vascularization, abnormal cardiogenesis and placental defects. Homozygotes for another null allele die by E10.5 with brain, neural crest, gut tube and heart anomalies.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    895
  • Tissues
    162
  • cDNA Data
    24
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 107586 NCBI Gene Model | MGI Sequence Detail 26906 C57BL/6J ±  kb
    transcript NM_026924 RefSeq | MGI Sequence Detail 1473 C57BL/6  
    polypeptide Q8CIV7 UniProt | EBI | MGI Sequence Detail 274 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 24
      Primer pair 5
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1916309
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 20
      Gene Ontology 15
      Phenotypes 18
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:354591 Jeyarajah MJ, et al., Placental extracellular vesicles promote cardiomyocyte maturation and fetal heart development. Commun Biol. 2024 Oct 3;7(1):1254
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory