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Noxa1 Gene Detail
Summary
  • Symbol
    Noxa1
  • Name
    NADPH oxidase activator 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2449980
    NCBI Gene: 241275
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:24975679-24985161 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 16.97 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    341 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2449980
 protein coding gene Chr2:24975679-24985217 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025420
 protein coding gene Chr2:22938634-22948116 (-)
A/J MGP_AJ_G0025397
 protein coding gene Chr2:22048651-22058109 (-)
AKR/J MGP_AKRJ_G0025367
 protein coding gene Chr2:22800825-22810309 (-)
BALB/cJ MGP_BALBcJ_G0025393
 protein coding gene Chr2:22171132-22180648 (-)
C3H/HeJ MGP_C3HHeJ_G0025154
 protein coding gene Chr2:22731568-22741042 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025837
 protein coding gene Chr2:23670716-23680184 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023248
 protein coding gene Chr2:20983543-20992931 (-)
CAST/EiJ MGP_CASTEiJ_G0024617
 protein coding gene Chr2:22616583-22626029 (-)
CBA/J MGP_CBAJ_G0025132
 protein coding gene Chr2:24504517-24514111 (-)
DBA/2J MGP_DBA2J_G0025265
 protein coding gene Chr2:21906908-21916392 (-)
FVB/NJ MGP_FVBNJ_G0025227
 protein coding gene Chr2:21644949-21654331 (-)
LP/J MGP_LPJ_G0025351
 protein coding gene Chr2:22886401-22895883 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025258
 protein coding gene Chr2:24718860-24728342 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025896
 protein coding gene Chr2:22743634-22753106 (-)
PWK/PhJ MGP_PWKPhJ_G0024365
 protein coding gene Chr2:21714959-21724400 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024165
 protein coding gene Chr2:22895474-22904918 (-)
WSB/EiJ MGP_WSBEiJ_G0024686
 protein coding gene Chr2:22820311-22829789 (-)



Homology
more
  • Human Ortholog
    NOXA1, NADPH oxidase activator 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NOXA1, NADPH oxidase activator 1
  • Synonyms
    NY-CO-31, p51NOX, SDCCAG31
  • Links
    NCBI Gene ID: 10811
    neXtProt AC: NX_Q86UR1
    UniProt: Q86UR1

  • Chr Location
    9q34.3; chr9:137423350-137434406 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 3 alleles in 3 genetic backgrounds
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele removing exons 3 through 6 exhibit no overt phenotypic abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    717
  • Tissues
    3
  • cDNA Data
    4
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036805 Ensembl Gene Model | MGI Sequence Detail 9483 C57BL/6J ±  kb
    transcript ENSMUST00000044018 Ensembl | MGI Sequence Detail 1617 Not Applicable  
    polypeptide ENSMUSP00000037423 Ensembl | MGI Sequence Detail 444 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 5
      cDNA 4
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 30
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 5
    • Earliest
      J:81679 Banfi B, et al., Two novel proteins activate superoxide generation by the NADPH oxidase NOX1. J Biol Chem. 2003 Feb 7;278(6):3510-3
    • Latest
      J:301595 Janus P, et al., Pro-death signaling of cytoprotective heat shock factor 1: upregulation of NOXA leading to apoptosis in heat-sensitive cells. Cell Death Differ. 2020 Jul;27(7):2280-2292
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory