Mical3 MGI Mouse Gene Detail - MGI:2442733 - microtubule associated monooxygenase, calponin and LIM domain containing 3

Symbol

Mical3
Name

microtubule associated monooxygenase, calponin and LIM domain containing 3
Synonyms

C130040D16Rik, MICAL-3, mKIAA1364

Feature Type

protein coding gene
IDs

MGI:2442733
NCBI Gene: 194401
Alliance

gene page
Transcription Start Sites

18 TSS

Sequence Map

Chr6:120908668-121107959 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 57.03 cM
Mapping Data

3 experiments

SNPs within 2kb

4117 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442733	protein coding gene	Chr6:120908507-121150716 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0031212	protein coding gene	Chr6:123852734-124062496 (-)
A/J	MGP_AJ_G0031181	protein coding gene	Chr6:119089246-119285190 (-)
AKR/J	MGP_AKRJ_G0031112	protein coding gene	Chr6:122312642-122508909 (-)
BALB/cJ	MGP_BALBcJ_G0031192	protein coding gene	Chr6:118849917-119052369 (-)
C3H/HeJ	MGP_C3HHeJ_G0030910	protein coding gene	Chr6:122327847-122533849 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031650	protein coding gene	Chr6:127030938-127245499 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028810	protein coding gene	Chr6:115987560-116184142 (-)
CAST/EiJ	MGP_CASTEiJ_G0030299	protein coding gene	Chr6:122762510-122973605 (-)
CBA/J	MGP_CBAJ_G0030875	protein coding gene	Chr6:132069353-132291425 (-)
DBA/2J	MGP_DBA2J_G0031031	protein coding gene	Chr6:117979374-118175508 (-)
FVB/NJ	MGP_FVBNJ_G0030983	protein coding gene	Chr6:117114682-117320892 (-)
LP/J	MGP_LPJ_G0031110	protein coding gene	Chr6:123849647-124051779 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031017	protein coding gene	Chr6:136037201-136239751 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031679	protein coding gene	Chr6:122328399-122538077 (-)
PWK/PhJ	MGP_PWKPhJ_G0030014	protein coding gene	Chr6:117018854-117217205 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0029843	protein coding gene	Chr6:121074991-121276861 (-)
WSB/EiJ	MGP_WSBEiJ_G0030382	protein coding gene	Chr6:122623788-122830583 (-)

Human Ortholog

MICAL3, microtubule associated monooxygenase, calponin and LIM domain containing 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MICAL3, microtubule associated monooxygenase, calponin and LIM domain containing 3
Synonyms

MICAL-3
Links

HGNC:24694

NCBI Gene ID: 57553

neXtProt AC: NX_Q7RTP6

UniProt: Q7RTP6
Chr Location

22q11.21; chr22:17787649-18024561 (-) GRCh38

MGI Vertebrate Homology

Mical3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MICAL3
Gene Tree

Mical3

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

1
Gene trapped

6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

83 strains or lines available

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All GO Annotations

27
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

893
Tissues

25
cDNA Data

15
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mical3

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All Sequences

155
RefSeq

63
UniProt

12
CCDS

CCDS20487.1, CCDS85152.1

Ensembl

ENSMUSG00000051586 (Evidence)
NCBI Gene

194401

			Length	Strain/Species	Flank
genomic	ENSMUSG00000051586	Ensembl Gene Model \| MGI Sequence Detail	199292	C57BL/6J	± kb
transcript	ENSMUST00000238968	Ensembl \| MGI Sequence Detail	9357	Not Applicable
polypeptide	ENSMUSP00000159123	Ensembl \| MGI Sequence Detail	2044	Not Applicable

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UniProt

12 Sequences
Protein Ontology

PR:000010401 [F-actin]-monooxygenase MICAL3

(term hierarchy)
EC

1.14.13.225
InterPro Domains

IPR022735 bMERB domain

IPR001715 Calponin homology domain

IPR036872 CH domain superfamily

IPR050540 F-actin Monooxygenase Mical

IPR002938 FAD-binding domain

IPR036188 FAD/NAD(P)-binding domain superfamily

IPR001781 Zinc finger, LIM-type
GlyGen

Q8CJ19 1 site, 1 O-linked glycan (1 site)

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All nucleic 17

Genomic 2

cDNA 15

Microarray probesets 4

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MGI:2673704

Summaries

All 35

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 5
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mical3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr62805	Chr6:121108030-121108039 (-)	-76 bp
Tssr62804	Chr6:121108010-121108025 (-)	-59 bp
Tssr62803	Chr6:121107973-121108009 (-)	-32 bp
Tssr62802	Chr6:121107953-121107964 (-)	0 bp
Tssr62801	Chr6:121087062-121087131 (-)	20,862 bp
Tssr62800	Chr6:121080482-121080490 (-)	27,473 bp
Tssr62799	Chr6:121058550-121058569 (-)	49,399 bp
Tssr62798	Chr6:121021085-121021089 (-)	86,872 bp
Tssr62797	Chr6:121008601-121008604 (-)	99,356 bp
Tssr62796	Chr6:121004407-121004420 (-)	103,545 bp
Tssr62795	Chr6:121004396-121004403 (-)	103,559 bp
Tssr62794	Chr6:120980060-120980095 (-)	127,881 bp
Tssr62793	Chr6:120980027-120980037 (-)	127,927 bp
Tssr62792	Chr6:120979995-120980013 (-)	127,955 bp
Tssr62791	Chr6:120979966-120979973 (-)	127,989 bp
Tssr62790	Chr6:120948570-120948599 (-)	159,374 bp
Tssr62789	Chr6:120948359-120948398 (-)	159,580 bp
Tssr62788	Chr6:120910766-120910770 (-)	197,191 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24