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Ago3 Gene Detail
Summary
  • Symbol
    Ago3
  • Name
    argonaute RISC catalytic subunit 3
  • Synonyms
    argonaute 3, C130014L07Rik, eIF2C3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2446634
    NCBI Gene: 214150
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:126225497-126323349 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 60.39 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2261 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2446634
 protein coding gene Chr4:126220797-126323360 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028780
 protein coding gene Chr4:128008345-128111321 (-)
A/J MGP_AJ_G0028739
 protein coding gene Chr4:122968442-123072968 (-)
AKR/J MGP_AKRJ_G0028692
 protein coding gene Chr4:126347855-126453252 (-)
BALB/cJ MGP_BALBcJ_G0028762
 protein coding gene Chr4:123544642-123644409 (-)
C3H/HeJ MGP_C3HHeJ_G0028476
 protein coding gene Chr4:126414829-126515709 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029204
 protein coding gene Chr4:132898683-132999484 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026477
 protein coding gene Chr4:116115615-116206141 (-)
CAST/EiJ MGP_CASTEiJ_G0027909
 protein coding gene Chr4:124521620-124625621 (-)
CBA/J MGP_CBAJ_G0028442
 protein coding gene Chr4:136098824-136200513 (-)
DBA/2J MGP_DBA2J_G0028591
 protein coding gene Chr4:123423097-123520872 (-)
FVB/NJ MGP_FVBNJ_G0028558
 protein coding gene Chr4:122079729-122173718 (-)
LP/J MGP_LPJ_G0028692
 protein coding gene Chr4:128294794-128397380 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028584
 protein coding gene Chr4:141133823-141240447 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029242
 protein coding gene Chr4:126704003-126807174 (-)
PWK/PhJ MGP_PWKPhJ_G0027630
 protein coding gene Chr4:119910999-120011314 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027456
 protein coding gene Chr4:122528741-122628550 (-)
WSB/EiJ MGP_WSBEiJ_G0027989
 protein coding gene Chr4:126803007-126919023 (-)



Homology
more
  • Human Ortholog
    AGO3, argonaute RISC catalytic component 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AGO3, argonaute RISC catalytic component 3
  • Synonyms
    EIF2C3
  • Links
    NCBI Gene ID: 192669
    neXtProt AC: NX_Q9H9G7
    UniProt: Q9H9G7

  • Chr Location
    1p34.3; chr1:35930718-36072500 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    31
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    3
  • Gene trapped
    22
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    5 involving Ago3
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
    66 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    49
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    781
  • Tissues
    40
  • cDNA Data
    17
  • Literature Summary
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028842 Ensembl Gene Model | MGI Sequence Detail 97853 C57BL/6J ±  kb
transcript ENSMUST00000069097 Ensembl | MGI Sequence Detail 15595 Not Applicable  
polypeptide ENSMUSP00000066633 Ensembl | MGI Sequence Detail 860 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 23
    cDNA 17
    Primer pair 5
    Other 1

    Microarray probesets 8
Other
Accession IDs
less
MGI:2140548, MGI:2443408
References
more
  • Summaries
    All 65
    Developmental Gene Expression 7
    Gene Ontology 11
    Phenotypes 22
  • Earliest
    J:79881 Carmell MA, et al., The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis. Genes Dev. 2002 Nov 1;16(21):2733-42
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory