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Rasgef1b Gene Detail
Summary
  • Symbol
    Rasgef1b
  • Name
    RasGEF domain family, member 1B
  • Synonyms
    4732452O09Rik, Gpig4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443755
    NCBI Gene: 320292
  • Alliance
    gene page
  • Transcription Start Sites
    23 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:99365279-99400786 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 48.46 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1041 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443755
 protein coding gene Chr5:99365279-99876924 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029779
 protein coding gene Chr5:100686765-101145385 (-)
A/J MGP_AJ_G0029745
 protein coding gene Chr5:96969759-97404107 (-)
AKR/J MGP_AKRJ_G0029691
 protein coding gene Chr5:100164696-100615759 (-)
BALB/cJ MGP_BALBcJ_G0029755
 protein coding gene Chr5:97985572-98423520 (-)
C3H/HeJ MGP_C3HHeJ_G0029478
 protein coding gene Chr5:100493410-100943704 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030210
 protein coding gene Chr5:104915366-105388385 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027445
 protein coding gene Chr5:92254971-92689312 (-)
CAST/EiJ MGP_CASTEiJ_G0028889
 protein coding gene Chr5:99144173-99606873 (-)
CBA/J MGP_CBAJ_G0029448
 protein coding gene Chr5:108524611-109001161 (-)
DBA/2J MGP_DBA2J_G0029592
 protein coding gene Chr5:97159432-97591990 (-)
FVB/NJ MGP_FVBNJ_G0029551
 protein coding gene Chr5:95975542-96408755 (-)
LP/J MGP_LPJ_G0029680
 protein coding gene Chr5:101305310-101767748 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029580
 protein coding gene Chr5:113651162-114119206 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030243
 protein coding gene Chr5:99625624-100084541 (-)
PWK/PhJ MGP_PWKPhJ_G0028607
 protein coding gene Chr5:95592764-96039038 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028442
 protein coding gene Chr5:97327722-97790829 (-)
WSB/EiJ MGP_WSBEiJ_G0028967
 protein coding gene Chr5:99953851-100410952 (-)



Homology
more
  • Human Ortholog
    RASGEF1B, RasGEF domain family member 1B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RASGEF1B, RasGEF domain family member 1B
  • Synonyms
    GPIG4
  • Links
    NCBI Gene ID: 153020
    neXtProt AC: NX_Q0VAM2
    UniProt: Q0VAM2

  • Chr Location
    4q21.21; chr4:81426393-82044244 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    4
  • Genomic Mutations
    3 involving Rasgef1b
  • Incidental Mutations
    Mutagenetix , APF
  • Find Mice (IMSR)
    41 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    812
  • Tissues
    23
  • cDNA Data
    24
  • Literature Summary
    10
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 320292 NCBI Gene Model | MGI Sequence Detail 35508 C57BL/6J ±  kb
transcript NM_145839 RefSeq | MGI Sequence Detail 2996 C57BL/6  
polypeptide Q8JZL7 UniProt | EBI | MGI Sequence Detail 473 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 26
    cDNA 24
    Primer pair 2

    Microarray probesets 4
References
more
  • Summaries
    All 46
    Developmental Gene Expression 10
    Gene Ontology 5
    Phenotypes 11
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory