Commd10 MGI Mouse Gene Detail - MGI:1916706

Symbol

Commd10
Name

COMM domain containing 10
Synonyms

2310003A05Rik, DRWMS2

Feature Type

protein coding gene
IDs

MGI:1916706
NCBI Gene: 69456
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr18:47091917-47242435 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 24.90 cM
Mapping Data

2 experiments

SNPs within 2kb

4153 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916706	protein coding gene	Chr18:47091883-47367351 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024416	protein coding gene	Chr18:45801161-45945305 (+)
A/J	MGP_AJ_G0024382	protein coding gene	Chr18:44137482-44273113 (+)
AKR/J	MGP_AKRJ_G0024351	protein coding gene	Chr18:45346502-45483126 (+)
BALB/cJ	MGP_BALBcJ_G0024382	protein coding gene	Chr18:44245768-44376324 (+)
C3H/HeJ	MGP_C3HHeJ_G0024149	protein coding gene	Chr18:45439634-45576985 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024827	protein coding gene	Chr18:47412952-47547679 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022261	protein coding gene	Chr18:43943494-44069609 (+)
CAST/EiJ	MGP_CASTEiJ_G0023624	protein coding gene	Chr18:45386036-45520337 (+)
CBA/J	MGP_CBAJ_G0024118	protein coding gene	Chr18:48693841-48847632 (+)
DBA/2J	MGP_DBA2J_G0024248	protein coding gene	Chr18:43744487-43875413 (+)
FVB/NJ	MGP_FVBNJ_G0024215	protein coding gene	Chr18:43312416-43441617 (+)
LP/J	MGP_LPJ_G0024333	protein coding gene	Chr18:45864950-46004430 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024246	protein coding gene	Chr18:50056483-50200631 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024874	protein coding gene	Chr18:45277504-45420245 (+)
PWK/PhJ	MGP_PWKPhJ_G0023367	protein coding gene	Chr18:43894974-44027472 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023173	protein coding gene	Chr18:45449048-45587653 (+)
WSB/EiJ	MGP_WSBEiJ_G0023687	protein coding gene	Chr18:45170008-45309320 (+)

Human Ortholog

COMMD10, COMM domain containing 10

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

COMMD10, COMM domain containing 10
Synonyms

PTD002
Links

HGNC:30201

NCBI Gene ID: 51397

neXtProt AC: NX_Q9Y6G5

UniProt: Q9Y6G5
Chr Location

5q23.1; chr5:116085016-116412762 (+) GRCh38

MGI Vertebrate Homology

Commd10 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: COMMD10
Gene Tree

Commd10

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Mutations/Alleles

1 with disease annotations

References

5 with disease annotations

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
243 phenotypes from multigenic genotypes
1 images
593 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Gene trapped

10
Spontaneous

1
Targeted

2
Transgenic

1
Genomic Mutations

1 involving Commd10
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit defects in placentation with abnormal trophoblast layer formation and complete lethality throughout fetal growth and development.

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All GO Annotations

3
GO References

3

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

55

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase commd10

ZFIN commd10

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All Sequences

88
RefSeq

27
UniProt

8
CCDS

CCDS29238.1

Ensembl

ENSMUSG00000042705 (Evidence)
NCBI Gene

69456

			Length	Strain/Species	Flank
genomic	69456	NCBI Gene Model \| MGI Sequence Detail	150519	C57BL/6J	± kb
transcript	NM_001418808	RefSeq \| MGI Sequence Detail	3690	C57BL/6
polypeptide	Q8JZY2	UniProt \| EBI \| MGI Sequence Detail	202	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000029366 COMM domain-containing protein 10

(term hierarchy)
InterPro Domains

IPR017920 COMM domain

IPR037361 COMM domain-containing protein 10

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All nucleic 55

cDNA 55

Microarray probesets 5

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MGI:2147306, MGI:2449945

Summaries

All 621

Diseases 5

Gene Ontology 3

Phenotypes 593
Earliest

J:140234 Ogilvy S, et al., Promoter elements of vav drive transgene expression in vivo throughout the hematopoietic compartment. Blood. 1999 Sep 15;94(6):1855-63
Latest

J:355519 Oberkircher LM, et al., Opposing roles of resident and infiltrating immune cells in the defense against Legionella longbeachae via IL-18R/IFN-gamma/ROS axis in mice. Mucosal Immunol. 2024 Oct;17(5):777-792

TSS for Commd10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr150968	Chr18:47091909-47091956 (+)	16 bp
Tssr150969	Chr18:47092674-47092680 (+)	760 bp
Tssr150970	Chr18:47173661-47173665 (+)	81,746 bp
Tssr150971	Chr18:47189120-47189138 (+)	97,212 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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