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Spata2 Gene Detail
Summary
  • Symbol
    Spata2
  • Name
    spermatogenesis associated 2
  • Synonyms
    MGC:38980
  • Feature Type
    protein coding gene
  • IDs
    MGI:2146885
    NCBI Gene: 263876
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:167323053-167334804 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 87.23 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    307 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2146885
 protein coding gene Chr2:167323053-167334807 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026913
 protein coding gene Chr2:173217786-173232360 (-)
A/J MGP_AJ_G0026880
 protein coding gene Chr2:166087366-166098412 (-)
AKR/J MGP_AKRJ_G0026851
 protein coding gene Chr2:171040013-171051806 (-)
BALB/cJ MGP_BALBcJ_G0026889
 protein coding gene Chr2:166444984-166456854 (-)
C3H/HeJ MGP_C3HHeJ_G0026631
 protein coding gene Chr2:171408793-171421851 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027336
 protein coding gene Chr2:178275499-178288367 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024707
 protein coding gene Chr2:159403675-159416071 (-)
CAST/EiJ MGP_CASTEiJ_G0026089
 protein coding gene Chr2:171873505-171885915 (-)
CBA/J MGP_CBAJ_G0026608
 protein coding gene Chr2:184809961-184826500 (-)
DBA/2J MGP_DBA2J_G0026746
 protein coding gene Chr2:165200245-165212987 (-)
FVB/NJ MGP_FVBNJ_G0026712
 protein coding gene Chr2:163726691-163740596 (-)
LP/J MGP_LPJ_G0026847
 protein coding gene Chr2:173235083-173245824 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026731
 protein coding gene Chr2:188194165-188208583 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027393
 protein coding gene Chr2:170971609-170984961 (-)
PWK/PhJ MGP_PWKPhJ_G0025826
 protein coding gene Chr2:164862006-164880144 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025627
 protein coding gene Chr2:169907991-169930453 (-)
WSB/EiJ MGP_WSBEiJ_G0026162
 protein coding gene Chr2:171878036-171892893 (-)



Homology
more
  • Human Ortholog
    SPATA2, spermatogenesis associated 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPATA2, spermatogenesis associated 2
  • Synonyms
    PD1, PPP1R145, tamo
  • Links
    NCBI Gene ID: 9825
    neXtProt AC: NX_Q9UM82
    UniProt: Q9UM82

  • Chr Location
    20q13.13; chr20:49903391-49915529 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 3 alleles in 3 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout leads to small testes, oligospermia, asthenozoospermia, reduced male fertility and decreased male germ cell numbers. It also affects necroptosis and increases inflammatory responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    809
  • Tissues
    59
  • cDNA Data
    13
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 263876 NCBI Gene Model | MGI Sequence Detail 11752 C57BL/6J ±  kb
    transcript NM_001411418 RefSeq | MGI Sequence Detail 4577 C57BL/6  
    polypeptide Q8K004 UniProt | EBI | MGI Sequence Detail 515 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 13
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 14
    • Earliest
      J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory