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Cenpo Gene Detail
Summary
  • Symbol
    Cenpo
  • Name
    centromere protein O
  • Synonyms
    2810429O05Rik, 8430427C03Rik, D12Ertd482e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923800
    NCBI Gene: 52504
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:4246004-4284294 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 2.02 cM, cytoband A1.1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    972 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923800
 protein coding gene Chr12:4243548-4284294 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019565
 protein coding gene Chr12:1063755-1104372 (-)
A/J MGP_AJ_G0019532
 protein coding gene Chr12:1081953-1117703 (-)
AKR/J MGP_AKRJ_G0019502
 protein coding gene Chr12:1238308-1277102 (-)
BALB/cJ MGP_BALBcJ_G0019507
 protein coding gene Chr12:1098599-1134675 (-)
C3H/HeJ MGP_C3HHeJ_G0019313
 protein coding gene Chr12:1025575-1061157 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019956
 protein coding gene Chr12:1093412-1131343 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017581
 protein coding gene Chr12:983267-1019634 (-)
CAST/EiJ MGP_CASTEiJ_G0018868
 protein coding gene Chr12:1092803-1128391 (-)
CBA/J MGP_CBAJ_G0019284
 protein coding gene Chr12:1362542-1399785 (-)
DBA/2J MGP_DBA2J_G0019397
 protein coding gene Chr12:1015701-1053407 (-)
FVB/NJ MGP_FVBNJ_G0019387
 protein coding gene Chr12:1040357-1075843 (-)
LP/J MGP_LPJ_G0019468
 protein coding gene Chr12:1081065-1118435 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019421
 protein coding gene Chr12:1147700-1185220 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019995
 protein coding gene Chr12:1019775-1059800 (-)
PWK/PhJ MGP_PWKPhJ_G0018634
 protein coding gene Chr12:1043896-1081473 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018425
 protein coding gene Chr12:1086583-1121600 (-)
WSB/EiJ MGP_WSBEiJ_G0018920
 protein coding gene Chr12:1044153-1080055 (-)



Homology
more
  • Human Ortholog
    CENPO, centromere protein O
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CENPO, centromere protein O
  • Synonyms
    CENP-O, ICEN-36, MCM21R
  • Links
    NCBI Gene ID: 79172
    neXtProt AC: NX_Q9BU64
    UniProt: Q9BU64

  • Chr Location
    2p23.3; chr2:24793136-24822376 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 1 allele in 1 genetic background
    1 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased embryo size, a rudimentary egg cylinder, failure of primitive streak formation, absent primitive node and head folds, failure to gastrulate, and complete embryonic lethality by E9.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    6
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    951
  • Tissues
    70
  • cDNA Data
    14
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020652 Ensembl Gene Model | MGI Sequence Detail 38291 C57BL/6J ±  kb
    transcript ENSMUST00000140975 Ensembl | MGI Sequence Detail 4348 Not Applicable  
    polypeptide ENSMUSP00000119136 Ensembl | MGI Sequence Detail 298 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 14
      Primer pair 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1196418, MGI:1918755, MGI:2144825
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 4
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory